AZANATOR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(CC1)=C2C3=C(OC4=C2C=CC=N4)C=CC=C3

InChI

InChIKey=ALIOEEFZPKWPAV-UHFFFAOYSA-N

InChI=1S/C18H18N2O/c1-20-11-8-13(9-12-20)17-14-5-2-3-7-16(14)21-18-15(17)6-4-10-19-18/h2-7,10H,8-9,11-12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/193512 | https://www.ncbi.nlm.nih.gov/pubmed/237114

Azanator (previously known as Sch 15280), a bronchodilator and an antihistamine drug that acts via a non-adrenergic mechanism to block both histaminergically and cholinergically mediated responses in the tracheobronchial tree. Besides, the drug inhibits cyclic CMP phosphodiesterase. Azanator can have a therapeutic application in cases of chronic cough and cystic fibrosis in man.

Approval Year

PubMed

Title	Date	PubMed
Effect of SCH 15280, a new bronchodilator, on cyclic 3',5'-nucleotide phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in guinea pig lung.	1977 May 15	193512
Differential effects of various phosphodiesterase inhibitors, pyrimidine and purine compounds, and inorganic phosphates on cyclic CMP, cyclic AMP and cyclic GMP phosphodiesterases.	1982 Jan 1	6277336

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:38:12 UTC 2023` Edited by `admin` on `Sat Dec 16 17:38:12 UTC 2023`
Record UNII	699725286I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZANATOR

Official Name

English

5H-(1)BENZOPYRANO(2,3-B)PYRIDINE, 5-(1-METHYL-4-PIPERIDINYLIDENE)-, (Z)-2-BUTENEDIOATE

Systematic Name

English

azanator [INN]

Common Name

English

5-(1-METHYL-4-PIPERIDYLIDENE)-5H-(1)BENZOPYRANO(2,3-B)PYRIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319