AZANATOR MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18N2O.C4H4O4
Molecular Weight	394.4205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C2C3=C(OC4=C2C=CC=N4)C=CC=C3

InChI

InChIKey=QXBGSDYYBBNBPB-BTJKTKAUSA-N

InChI=1S/C18H18N2O.C4H4O4/c1-20-11-8-13(9-12-20)17-14-5-2-3-7-16(14)21-18-15(17)6-4-10-19-18;5-3(6)1-2-4(7)8/h2-7,10H,8-9,11-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/193512 | https://www.ncbi.nlm.nih.gov/pubmed/237114

Azanator (previously known as Sch 15280), a bronchodilator and an antihistamine drug that acts via a non-adrenergic mechanism to block both histaminergically and cholinergically mediated responses in the tracheobronchial tree. Besides, the drug inhibits cyclic CMP phosphodiesterase. Azanator can have a therapeutic application in cases of chronic cough and cystic fibrosis in man.

Approval Year

PubMed

Title	Date	PubMed
Effect of SCH 15280, a new bronchodilator, on cyclic 3',5'-nucleotide phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in guinea pig lung.	1977 May 15	193512

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:58 UTC 2023` Edited by `admin` on `Fri Dec 15 15:32:58 UTC 2023`
Record UNII	63ISF1PDWX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZANATOR MALEATE

Official Name

English

AZANATOR MALEATE [USAN]

Common Name

English

5H-(1)BENZOPYRANO(2,3-B)PYRIDINE, 5-(1-METHYL-4-PIPERIDINYLIDENE)-, (Z)-2-BUTENEDIOATE (1:1)

Systematic Name

English

SCH-15280

Code

English

5-(1-Methyl-4-piperidylidene)-5H-[1]benzopyrano[2,3-b]pyridine maleate (1:1)

Systematic Name

English

5-(4-(N-METHYL)-PIPERIDYLIDENE)-5H-(1)-BENZOPYRANO(2,3-B)PYRIDINE MALEATE

Common Name

English

NSC-295279

Code

English

SCH 15280

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C319