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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18N2O.C4H4O4
Molecular Weight 394.4205
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of AZANATOR MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C2C3=CC=CC=C3OC4=NC=CC=C24

InChI

InChIKey=QXBGSDYYBBNBPB-BTJKTKAUSA-N
InChI=1S/C18H18N2O.C4H4O4/c1-20-11-8-13(9-12-20)17-14-5-2-3-7-16(14)21-18-15(17)6-4-10-19-18;5-3(6)1-2-4(7)8/h2-7,10H,8-9,11-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C18H18N2O
Molecular Weight 278.3483
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Azanator (previously known as Sch 15280), a bronchodilator and an antihistamine drug that acts via a non-adrenergic mechanism to block both histaminergically and cholinergically mediated responses in the tracheobronchial tree. Besides, the drug inhibits cyclic CMP phosphodiesterase. Azanator can have a therapeutic application in cases of chronic cough and cystic fibrosis in man.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effect of SCH 15280, a new bronchodilator, on cyclic 3',5'-nucleotide phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in guinea pig lung.
1977 May 15
Differential effects of various phosphodiesterase inhibitors, pyrimidine and purine compounds, and inorganic phosphates on cyclic CMP, cyclic AMP and cyclic GMP phosphodiesterases.
1982 Jan 1
Substance Class Chemical
Created
by admin
on Tue Oct 22 05:38:01 UTC 2019
Edited
by admin
on Tue Oct 22 05:38:01 UTC 2019
Record UNII
63ISF1PDWX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZANATOR MALEATE
USAN  
USAN  
Official Name English
AZANATOR MALEATE [USAN]
Common Name English
5H-(1)BENZOPYRANO(2,3-B)PYRIDINE, 5-(1-METHYL-4-PIPERIDINYLIDENE)-, (Z)-2-BUTENEDIOATE (1:1)
Systematic Name English
SCH-15280
Code English
5-(1-METHYL-4-PIPERIDYLIDENE)-5H-(1)BENZOPYRANO(2,3-B)PYRIDINE MALEATE (1:1)
Systematic Name English
5-(4-(N-METHYL)-PIPERIDYLIDENE)-5H-(1)-BENZOPYRANO(2,3-B)PYRIDINE MALEATE
Common Name English
SCH 15280
Code English
Classification Tree Code System Code
NCI_THESAURUS C319
Created by admin on Tue Oct 22 05:38:01 UTC 2019 , Edited by admin on Tue Oct 22 05:38:01 UTC 2019
Code System Code Type Description
NCI_THESAURUS
C74219
Created by admin on Tue Oct 22 05:38:01 UTC 2019 , Edited by admin on Tue Oct 22 05:38:01 UTC 2019
PRIMARY
CAS
39624-65-2
Created by admin on Tue Oct 22 05:38:01 UTC 2019 , Edited by admin on Tue Oct 22 05:38:01 UTC 2019
PRIMARY
ChEMBL
CHEMBL2110934
Created by admin on Tue Oct 22 05:38:01 UTC 2019 , Edited by admin on Tue Oct 22 05:38:01 UTC 2019
PRIMARY
PUBCHEM
5359048
Created by admin on Tue Oct 22 05:38:01 UTC 2019 , Edited by admin on Tue Oct 22 05:38:01 UTC 2019
PRIMARY
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ACTIVE MOIETY