AZANATOR MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18N2O.C4H4O4
Molecular Weight	394.4205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1CCC(CC1)=C2C3=CC=CC=C3OC4=NC=CC=C24

InChI

InChIKey=QXBGSDYYBBNBPB-BTJKTKAUSA-N

InChI=1S/C18H18N2O.C4H4O4/c1-20-11-8-13(9-12-20)17-14-5-2-3-7-16(14)21-18-15(17)6-4-10-19-18;5-3(6)1-2-4(7)8/h2-7,10H,8-9,11-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/193512 | https://www.ncbi.nlm.nih.gov/pubmed/237114

Azanator (previously known as Sch 15280), a bronchodilator and an antihistamine drug that acts via a non-adrenergic mechanism to block both histaminergically and cholinergically mediated responses in the tracheobronchial tree. Besides, the drug inhibits cyclic CMP phosphodiesterase. Azanator can have a therapeutic application in cases of chronic cough and cystic fibrosis in man.

Approval Year

PubMed

Title	Date	PubMed
Differential effects of various phosphodiesterase inhibitors, pyrimidine and purine compounds, and inorganic phosphates on cyclic CMP, cyclic AMP and cyclic GMP phosphodiesterases.	1982-01-01	6277336
Effect of SCH 15280, a new bronchodilator, on cyclic 3',5'-nucleotide phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in guinea pig lung.	1977-05-15	193512

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:00:49 GMT 2025` Edited by `admin` on `Mon Mar 31 18:00:49 GMT 2025`
Record UNII	63ISF1PDWX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZANATOR MALEATE

Official Name

English

NSC-295279

Preferred Name

English

AZANATOR MALEATE [USAN]

Common Name

English

5H-(1)BENZOPYRANO(2,3-B)PYRIDINE, 5-(1-METHYL-4-PIPERIDINYLIDENE)-, (Z)-2-BUTENEDIOATE (1:1)

Systematic Name

English

SCH-15280

Code

English

5-(1-Methyl-4-piperidylidene)-5H-[1]benzopyrano[2,3-b]pyridine maleate (1:1)

Systematic Name

English

5-(4-(N-METHYL)-PIPERIDYLIDENE)-5H-(1)-BENZOPYRANO(2,3-B)PYRIDINE MALEATE

Common Name

English

SCH 15280

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C319