Sinapic acid is one of the most common hydroxycinnamic acids and is widespread in the plant kingdom. It has been identified in various fruits, vegetables, cereal grains, oilseed crops, some spices, and medicinal plants. Sinapic acid and its derivatives possess antimicrobial, antioxidant, anti-inflammatory, anticancer and anti-anxiety activities.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2093872 |
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Target ID: map04064 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
Sample Use Guides
Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants) and as such is common in the human diet.
Route of Administration:
Oral
Sinapic acid fraction isolated from the ethanolic extract of rapeseed was found to be highly effective against the growth of Gram-negative (Escherichia coli, Enterobacter aerogens, and Pseudomonas fluorescens) and Gram-positive (Bacillus subtilis, Bacillus cereus, Streptococcus lactis, and Streptococcus cremoris) bacteria. Antibacterial properties were determined on a solid foundation by the tile method and in liquid cultures. After 48 h of incubation with sinapic acid on a solid foundation, no growth of cells was observed. In the case of liquid cultures, the introduction of 0.6% sinapic acid caused a decrease in the numbers of live cells by 97.7% to 99.1% after 48 h of incubation. For B. cereus, S. lactis, and P. fluorescens it caused total inhibition of their growth.
| Substance Class |
Mixture
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| Record UNII |
68A28V6010
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Validated (UNII)
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Sinapic acid
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DB08587
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All of the following components must be present:
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Sinapic acid content for water extract of plant leaf was 9.03+/-0.17 and plant callus was 0.39+/-0.53 expressed as mg/100 g of dry base of extract.
For the analysis of phenolic acids, a Nova pack C18 UG120 equipped with a Guard column, a JASCO HPLC system consisting of a column oven, a UV-Vis diode array detector set at 280 nm, a Liquid chromatography pump and a ChromNAV software program were used.
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