Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H11N |
| Molecular Weight | 85.1475 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CCNCC1
InChI
InChIKey=NQRYJNQNLNOLGT-UHFFFAOYSA-N
InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
| Molecular Formula | C5H11N |
| Molecular Weight | 85.1475 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Piperidine is a normal constituent in mammalian brain. It was shown to affect synaptic mechanism in the CNS, and influence neural mechanisms governing regulation of emotional behavior, sleeping, and extrapyramidal function. In addition, there are enzyme systems within the brain that synthesize and metabolize piperidine, and uptake and storage mechanisms for piperidine are found in the nerve endings. Piperidine, which proved to be a highly effective “antipsychotomimetic” agent in rats, has been reported to bring about substantial improvement in a variety of schizophrenic patients.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2. | 2000 Jun |
|
| Copper-dependent DNA damage induced by hydrazobenzene, an azobenzene metabolite. | 2000 Jun |
|
| [The prescription of repellents]. | 2001 |
|
| Chemical cross-linking of drugs to DNA. | 2001 |
|
| Capturing a photoexcited molecular structure through time-domain x-ray absorption fine structure. | 2001 Apr 13 |
|
| Zwitterionic 4-piperidinecarboxylic acid monohydrate. | 2001 Aug |
|
| Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol. | 2001 Aug |
|
| Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and their relation to the inhibition of sodium channels. | 2001 Aug 10 |
|
| Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists. | 2001 Aug 20 |
|
| Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. | 2001 Aug 20 |
|
| Ntg2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxyguanine. | 2001 Aug 3 |
|
| Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet. | 2001 Feb 12 |
|
| Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines. | 2001 Feb 16 |
|
| [[Intramolecular alkylation of aromatic compounds. 35. Di- and tetrahydropyridinemethylindolines as potential precursors of ergolines] ]. | 2001 Jan |
|
| Bound transcription factor suppresses photoproduct formation in the NF-kappa B promoter. | 2001 Jan |
|
| Guanine versus deoxyribose damage in DNA oxidation mediated by vanadium(IV) and vanadium(V) complexes. | 2001 Jan |
|
| Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae). | 2001 Jan |
|
| Piperidine renin inhibitors: from leads to drug candidates. | 2001 Jan-Feb |
|
| [Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals]. | 2001 Jan-Mar |
|
| Selective, sensitive, and rapid phosphopeptide identification in enzymatic digests using ESI-FTICR-MS with infrared multiphoton dissociation. | 2001 Jul 15 |
|
| Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics. | 2001 Jul 23 |
|
| Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. | 2001 Jun |
|
| Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block. | 2001 Jun |
|
| Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment. | 2001 Mar |
|
| A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. | 2001 Mar 15 |
|
| A universal, photocleavable DNA base: nitropiperonyl 2'-deoxyriboside. | 2001 Mar 23 |
|
| An improved and easy method for the preparation of 2,2-disubstituted 1-nitroalkenes. | 2001 Mar 23 |
|
| A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4. | 2001 Nov |
|
| Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. | 2001 Nov 5 |
|
| Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. | 2001 Nov 8 |
|
| In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. | 2001 Oct |
|
| Beef cattle losses after grazing Lupinus argenteus (silvery lupine). | 2001 Oct |
|
| Methyl (SR)-10-chloro-1,2,3,4,5,6-hexahydro-6-hydroxy-8-methoxy-1-methyl-1,9-phenanthroline-6-carboxylate. | 2001 Sep |
|
| 1-(2-[4-[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiol-3-ylcarbonyl]phenoxy]ethyl)piperidinium chloride. | 2001 Sep |
|
| Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent. | 2001 Sep |
|
| Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco. | 2001 Sep 21 |
|
| Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl 4-nitrophenyl thionocarbonates with alicyclic amines. | 2001 Sep 7 |
|
| Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene. | 2002 Jan 18 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:00:56 GMT 2025
by
admin
on
Mon Mar 31 19:00:56 GMT 2025
|
| Record UNII |
67I85E138Y
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
CFR |
21 CFR 172.515
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
||
|
JECFA EVALUATION |
PIPERIDINE
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
||
|
DEA NO. |
2704
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
67I85E138Y
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
C032727
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
SUB33956
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
8082
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
DTXSID6021165
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
110-89-4
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
m8850
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | Merck Index | ||
|
100000127745
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
Piperidine
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
114
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
203-813-0
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
589779
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
1596
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY | |||
|
18049
Created by
admin on Mon Mar 31 19:00:56 GMT 2025 , Edited by admin on Mon Mar 31 19:00:56 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT->PRECURSOR |
|
||
|
DERIVATIVE -> PARENT |
|
||
|
|
SALT/SOLVATE -> PARENT |
|
||
|
|
SALT/SOLVATE -> PARENT |
|
||
|
|
SALT/SOLVATE -> PARENT |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
