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Details

Stereochemistry ACHIRAL
Molecular Formula C5H11N
Molecular Weight 85.1475
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIPERIDINE

SMILES

C1CCNCC1

InChI

InChIKey=NQRYJNQNLNOLGT-UHFFFAOYSA-N
InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

HIDE SMILES / InChI

Molecular Formula C5H11N
Molecular Weight 85.1475
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Piperidine is a normal constituent in mammalian brain. It was shown to affect synaptic mechanism in the CNS, and influence neural mechanisms governing regulation of emotional behavior, sleeping, and extrapyramidal function. In addition, there are enzyme systems within the brain that synthesize and metabolize piperidine, and uptake and storage mechanisms for piperidine are found in the nerve endings. Piperidine, which proved to be a highly effective “antipsychotomimetic” agent in rats, has been reported to bring about substantial improvement in a variety of schizophrenic patients.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Drug as perpetrator​

Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2.
2000 Jun
Chemical cross-linking of drugs to DNA.
2001
Syntheses of the first amine-dicarboxyboranes and their bis(methylester) and bis(N-ethylamide) derivatives.
2001 Apr 9
A cytochrome P450 and a ferredoxin isolated from Mycobacterium sp. strain HE5 after growth on morpholine.
2001 Aug
Zwitterionic 4-piperidinecarboxylic acid monohydrate.
2001 Aug
Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol.
2001 Aug
Ntg2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxyguanine.
2001 Aug 3
Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet.
2001 Feb 12
Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines.
2001 Feb 16
Efficient synthesis of piperidine derivatives. Development of metal triflate-catalyzed diastereoselective nucleophilic substitution reactions of 2-methoxy- and 2-acyloxypiperidines.
2001 Feb 9
[[Intramolecular alkylation of aromatic compounds. 35. Di- and tetrahydropyridinemethylindolines as potential precursors of ergolines] ].
2001 Jan
Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae).
2001 Jan
Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.
2001 Jan 22
[Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals].
2001 Jan-Mar
Piperidine as an efficient organic catalyst of derivatization of oligosaccharides with malononitrile for high-sensitivity electrospray ionization mass analysis.
2001 Jul
Piperidinium 3-[(4-hydroxy-5-dimethyl-2-oxo-2H-chromen-3-yl)-phenylmethyl]-5,7-dimethyl-2-oxo-2H-chromen-4-olate.
2001 Jul
Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block.
2001 Jun
Synthesis and structure-activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores.
2001 Mar
A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.
2001 Mar 15
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
2001 May 24
Synthesis of DTPA analogues derived from piperidine and azepane: potential contrast enhancement agents for magnetic resonance imaging.
2001 Nov 16
Reductive demercuration in deprotection of trityl thioethers, trityl amines, and trityl ethers.
2001 Nov 16
Stereoselective total synthesis of (+/-)-thielocin A1beta.
2001 Nov 21
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.
2001 Nov 22
The role of species-dependent metabolism in the regional brain retention of 18F-labeled muscarinic acetylcholine receptor ligands.
2001 Oct
Beef cattle losses after grazing Lupinus argenteus (silvery lupine).
2001 Oct
Polar nitrogen compounds and their behaviour in the drinking water treatment process.
2001 Oct
Palladium-catalyzed cyclization of allylsilanes with nucleophilic displacement of the silyl group.
2001 Oct 1
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA.
2001 Oct 26
1-(2-[4-[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiol-3-ylcarbonyl]phenoxy]ethyl)piperidinium chloride.
2001 Sep
[Neonatal EEG trace of burst suppression. Etiological and evolutionary factors].
2001 Sep 16-30
Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl 4-nitrophenyl thionocarbonates with alicyclic amines.
2001 Sep 7
Cytotoxic activity of 2-aminomethylene-3(2H)-benzofuranones against human oral tumor cell lines.
2001 Sep-Oct
Synthesis and anti-HIV activity of some isatin derivatives.
2001 Sep-Oct
DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis.
2002 Apr 8
(3R,4S)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine: conformation and structure monitoring by vibrational circular dichroism.
2002 Jan 11
Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene.
2002 Jan 18
Antifungal amides from Piper arboreum and Piper tuberculatum.
2002 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Thu Jul 06 01:19:07 UTC 2023
Edited
by admin
on Thu Jul 06 01:19:07 UTC 2023
Record UNII
67I85E138Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PIPERIDINE
FCC   FHFI   HSDB   MI   WHO-DD  
Systematic Name English
Piperidine [WHO-DD]
Common Name English
FEMA NO. 2908
Code English
PIPERIDINE [FCC]
Common Name English
PIPERIDINE [FHFI]
Common Name English
PIPERIDINE [MI]
Common Name English
PYRIDINE, HEXAHYDRO-
Systematic Name English
CYCLOPENTIMINE
Common Name English
PIPERIDINE [HSDB]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 172.515
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
JECFA EVALUATION PIPERIDINE
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
DEA NO. 2704
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
Code System Code Type Description
FDA UNII
67I85E138Y
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
MESH
C032727
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
EVMPD
SUB33956
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
PUBCHEM
8082
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
EPA CompTox
DTXSID6021165
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
CAS
110-89-4
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
MERCK INDEX
M8850
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY Merck Index
SMS_ID
100000127745
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
WIKIPEDIA
Piperidine
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
HSDB
114
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
ECHA (EC/EINECS)
203-813-0
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
CHEBI
589779
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
CHEBI
18049
Created by admin on Thu Jul 06 01:19:07 UTC 2023 , Edited by admin on Thu Jul 06 01:19:07 UTC 2023
PRIMARY
Related Record Type Details
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DERIVATIVE -> PARENT
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SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
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ACTIVE MOIETY