U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Substance P is an undecapeptide member of the tachykinin neuropeptide family mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation. The endogenous receptor for substance P is neurokinin 1 receptor although it also activates neurokinin 2 and neurokinin 3. Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction. It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium. In contrast to other neuropeptides studied in human skin, substance P-induced vasodilatation has been found to decline during continuous infusion. Preclinical data support the notion that Substance P is an important element in pain perception. The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection or injury. Substance P appears to have an important role in nausea and vomiting. In 2004, the NK1 antagonist aprepitant (brand name Emend) was approved by the U.S. FDA for the treatment of chemotherapy-induced nausea and vomiting

Approval Year

PubMed

PubMed

TitleDatePubMed
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
1993 Mar 31
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
1997 Jun
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
2001 Feb 16
Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.
2001 Mar 27
Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.
2002 Jan
Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies.
2004 Aug 15
Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus.
2019 Nov
Patents

Patents

Sample Use Guides

Substance P 45nmol/kg intra-celiac artery, single treatment
Route of Administration: Intra-arterial
Substance Class Protein
Created
by admin
on Sat Dec 16 08:13:19 GMT 2023
Edited
by admin
on Sat Dec 16 08:13:19 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
675VGV5J1D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SUBSTANCE P
MI  
Common Name English
SUBSTANCE P [MI]
Common Name English
Substance P (1-11)
Common Name English
SUBSTANCE P (SMOOTH-MUSCLE STIMULANT)
Common Name English
L-Methioninamide, L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
Common Name English
Neuropeptide SP-1
Common Name English
SH-OLIGOPEPTIDE-73 [INCI]
Common Name English
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
Systematic Name English
Neurokinin P
Common Name English
SH-OLIGOPEPTIDE-73
INCI  
INCI  
Official Name English
Classification Tree Code System Code
LOINC 2971-0
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
LOINC 34630-4
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
Code System Code Type Description
WIKIPEDIA
SUBSTANCE P
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
FDA UNII
675VGV5J1D
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
MESH
D013373
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
PUBCHEM
36511
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
MERCK INDEX
m10263
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY Merck Index
CAS
33507-63-0
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
EVMPD
SUB130895
Created by admin on Sat Dec 16 08:13:19 GMT 2023 , Edited by admin on Sat Dec 16 08:13:19 GMT 2023
PRIMARY
Related Record Type Details
INHIBITOR OF RELEASE->TARGET
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL