Fusafungine, also known as fusafungin, is a cyclic depsipeptide antibiotic from Fusarium lateririum used for the treatment of nasal and throat infection including sinusitis, rhinitis, rhinopharyngitis, angina, laryngitis, and tracheitis. Fusafungine consists of a mixture of enniatins and has been widely used over the past 50 years. Its first authorization in the EU was in 1963. Fusafungine showed bacteriostatic activity against a suite of microorganisms, such as Mycoplasma pneumoniae, Legionella pneumophila, Streptococcus pneumoniae, S. pyogenes, and Staphylococcus aureus, including methicillin-resistant S. aureus. Besides its bacteriostatic activity against most micro-organisms involved in respiratory tract infections fusafungine displays original anti-inflammatory properties. Fusafungine has multiple mechanisms of action, including downregulation of the expression of intercellular adhesion molecule-1 (ICAM-1) and inhibition of production of proinflammatory cytokines. In September 2015, an EU-wide assessment of the benefit-risk of fusafungine was initiated due to an increase in the reporting rate of serious allergic reactions. European Medicines Agency (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) recommended that fusafungine should be withdrawn from the EU market
Approval Year
Substance Class |
Mixture
Created
by
admin
on
Edited
Sat Dec 16 20:22:27 UTC 2023
by
admin
on
Sat Dec 16 20:22:27 UTC 2023
|
Record UNII |
65DD690W0C
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-VATC |
QR02AB03
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
||
|
WHO-ATC |
R02AB03
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
1393-87-9
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
C166903
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
CHEMBL2109188
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
m5612
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | Merck Index | ||
|
5112
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
215-737-5
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
3084092
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
DB08965
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
25437
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | RxNorm | ||
|
65DD690W0C
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
347
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
FUSAFUNGINE
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY | |||
|
SUB02290MIG
Created by
admin on Sat Dec 16 20:22:27 UTC 2023 , Edited by admin on Sat Dec 16 20:22:27 UTC 2023
|
PRIMARY |
All of the following components must be present:
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
|