TELAPRISTONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H37NO4
Molecular Weight	463.6084
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)C5=CC=C(C=C5)N(C)C

InChI

InChIKey=BHERMCLNVOVDPU-DQFOBABISA-N

InChI=1S/C29H37NO4/c1-28-16-24(18-5-8-20(9-6-18)30(2)3)27-22-12-10-21(31)15-19(22)7-11-23(27)25(28)13-14-29(28,33)26(32)17-34-4/h5-6,8-9,15,23-25,33H,7,10-14,16-17H2,1-4H3/t23-,24+,25-,28-,29-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C29H37NO4
Molecular Weight	463.6084
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22028249 | https://clinicaltrials.gov/ct2/show/NCT01728454 | https://clinicaltrials.gov/ct2/show/NCT00874302 | https://www.globenewswire.com/news-release/2017/07/17/1047288/0/en/Repros-Announces-Proellex-Development-Program-Will-Remain-on-Partial-Clinical-Hold-by-the-FDA.html | https://clinicaltrials.gov/ct2/show/NCT01800422https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C104057

Telapristone is an orally available 21-substituted-19-nor-progestin and selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Its acetate form, the telapristone Acetate is a clinically used and a studied drug.

Originator

Approval Year

PubMed

Title	Date	PubMed
Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.	2018-10-01	30203004
A peek into the drug development scenario of endometriosis - A systematic review.	2017-06	28407578
Population pharmacokinetics of telapristone (CDB-4124) and its active monodemethylated metabolite CDB-4453, with a mixture model for total clearance.	2011-12	22028249

Patents

Sample Use Guides

In Vivo Use Guide

Endometriosis: capsules (6 and 12 mg), once a day for 18 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:56:48 GMT 2025` Edited by `admin` on `Mon Mar 31 19:56:48 GMT 2025`
Record UNII	65703MV349
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TELAPRISTONE

Official Name

English

11.BETA.-(4-(DIMETHYLAMINO)PHENYL)-17-HYDROXY-21-METHOXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE

Preferred Name

English

telapristone [INN]

Common Name

English

Telapristone [WHO-DD]

Common Name

English

19-NORPREGNA-4,9-DIENE-3,20-DIONE, 17-HYDROXY-11-(4-(DIMETHYLAMINO)PHENYL)-21-METHOXY-, (11.BETA.)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1891