MAPINASTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H34N6O
Molecular Weight	410.5557
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOCCN1C(CN2CCN(CCCCN3C=CC=N3)CC2)=NC4=C1C=CC=C4

InChI

InChIKey=CXFNDBLYDZRFQL-UHFFFAOYSA-N

InChI=1S/C23H34N6O/c1-2-30-19-18-29-22-9-4-3-8-21(22)25-23(29)20-27-16-14-26(15-17-27)11-5-6-12-28-13-7-10-24-28/h3-4,7-10,13H,2,5-6,11-12,14-20H2,1H3

HIDE SMILES / InChI

Molecular Formula	C23H34N6O
Molecular Weight	410.5557
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800003659 | https://www.ncbi.nlm.nih.gov/pubmed/8892269 | https://www.ncbi.nlm.nih.gov/pubmed/8900220 | https://www.ncbi.nlm.nih.gov/pubmed/9646282

Mapinastine (E 4716) is a selective antagonist of histamine H1 receptors. In animal models, mapinastine exerts antiallergic and anti-asthmatic properties. It demonstrated a lack of central effects. Mapinastine development has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 316 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8892269 \| https://www.ncbi.nlm.nih.gov/pubmed/9646282	Antagonist 2849

PubMed

Title	Date	PubMed
General pharmacological profile and effects of E-4716, a novel histamine receptor blocker, on the central nervous system.	1998-04	9646282
Effects of E-4716, a new antihistaminic with antiallergic properties, on chemical mediators induction of immunologic reactions.	1996-07-01	8892269

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:22:47 GMT 2025` Edited by `admin` on `Mon Mar 31 18:22:47 GMT 2025`
Record UNII	62LN840SFZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAPINASTINE

Official Name

English

mapinastine [INN]

Preferred Name

English

1-(2-ETHOXYETHYL)-2-((4-(4-PYRAZOL-1-YLBUTYL)-1-PIPERAZINYL)METHYL)BENZIMIDAZOLE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578