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Details

Stereochemistry ACHIRAL
Molecular Formula C9H13NO2P.Na
Molecular Weight 221.1686
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLDIMFOS SODIUM

SMILES

[Na+].CN(C)C1=CC=C(C(C)=C1)P([O-])=O

InChI

InChIKey=GTDKCTURAUQAGE-UHFFFAOYSA-M
InChI=1S/C9H14NO2P.Na/c1-7-6-8(10(2)3)4-5-9(7)13(11)12;/h4-6,13H,1-3H3,(H,11,12);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C9H13NO2P
Molecular Weight 198.1788
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Toldimfos is an aromatic phosphorus compound which falls between phosphorous itself and phosphoric acid in the stages of oxidation. Toldimfos sodium is the sodium salt of 2- methyl-4-(dimethylamino)phenylphosphinic acid. It is used to treat and prevent diseases associated with parturition and peri-partum period, developmental and nutritional disorders in young animals, and bone growth disorders and tetany or paresis caused by calcium, magnesium, and phosphorus metabolism disorders. Toldimfos has been used as a human medicine since 1920. While it is no longer indicated for human use, it is used in horses, cattle, sheep, pigs, and goats, and administered by intravenous, intramuscular, or subcutaneous injection. No specific data on the pharmacodynamic action of toldimfos was submitted. The precise mode of action of toldimfos is unknown and it is questionable whether the effect of toldimfos is simply a matter of the substitution of deficient phosphorus. It appears more likely that the effect of toldimfos arises due to multiple stimulation of metabolism with the body.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Note on the preparation of stable solutions of tonofosfan intended for parenteral use].
1949
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity.
2012 Oct
Analysis of toldimfos in porcine muscle and bovine milk using liquid chromatography-triple quadrupole mass spectrometry.
2017 Nov
Patents

Patents

Sample Use Guides

In Vivo Use Guide
10 mg/kg per injection, with a maximum treatment of 10 injections
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:13 GMT 2023
Edited
by admin
on Fri Dec 15 15:46:13 GMT 2023
Record UNII
6139240O1E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOLDIMFOS SODIUM
MI  
Common Name English
TONOPHOSPHAN
Brand Name English
NOVOFOSFAN
Brand Name English
TONOFOSFAN
Brand Name English
SODIUM (4-DIMETHYLAMINO-O-TOLYL)PHOSPHONATE
Common Name English
PHINIPHOS
Brand Name English
PHOSODYL
Brand Name English
P-DIMETHYLAMINO-O-TOLUENEPHOSPHONOUS ACID SODIUM SALT
Common Name English
P-(4-(DIMETHYLAMINO)-2-METHYLPHENYL)PHOSPHINIC ACID SODIUM SALT (1:1)
Common Name English
TOLDIMFOS SODIUM [MI]
Common Name English
PHOSPHINIC ACID, P-(4-(DIMETHYLAMINO)-2-METHYLPHENYL)-, SODIUM SALT (1:1)
Common Name English
FOSTON
Brand Name English
(4-DIMETHYLAMINO-O-TOLYL)PHOSPHONOUS ACID SODIUM SALT
Common Name English
Code System Code Type Description
PUBCHEM
68467
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
RXCUI
2001183
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
FDA UNII
6139240O1E
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
SMS_ID
300000023611
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-391-4
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
CAS
575-75-7
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID4060361
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY
MERCK INDEX
m10942
Created by admin on Fri Dec 15 15:46:13 GMT 2023 , Edited by admin on Fri Dec 15 15:46:13 GMT 2023
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
Related Record Type Details
ACTIVE MOIETY