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Details

Stereochemistry ACHIRAL
Molecular Formula C9H14NO2P
Molecular Weight 199.1867
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLDIMFOS

SMILES

CN(C)C1=CC=C(C(C)=C1)P(O)=O

InChI

InChIKey=KISUENOXDRDPHR-UHFFFAOYSA-N
InChI=1S/C9H14NO2P/c1-7-6-8(10(2)3)4-5-9(7)13(11)12/h4-6,13H,1-3H3,(H,11,12)

HIDE SMILES / InChI

Molecular Formula C9H14NO2P
Molecular Weight 199.1867
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Toldimfos is an aromatic phosphorus compound which falls between phosphorous itself and phosphoric acid in the stages of oxidation. Toldimfos sodium is the sodium salt of 2- methyl-4-(dimethylamino)phenylphosphinic acid. It is used to treat and prevent diseases associated with parturition and peri-partum period, developmental and nutritional disorders in young animals, and bone growth disorders and tetany or paresis caused by calcium, magnesium, and phosphorus metabolism disorders. Toldimfos has been used as a human medicine since 1920. While it is no longer indicated for human use, it is used in horses, cattle, sheep, pigs, and goats, and administered by intravenous, intramuscular, or subcutaneous injection. No specific data on the pharmacodynamic action of toldimfos was submitted. The precise mode of action of toldimfos is unknown and it is questionable whether the effect of toldimfos is simply a matter of the substitution of deficient phosphorus. It appears more likely that the effect of toldimfos arises due to multiple stimulation of metabolism with the body.

Approval Year

PubMed

PubMed

TitleDatePubMed
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity.
2012 Oct
Analysis of toldimfos in porcine muscle and bovine milk using liquid chromatography-triple quadrupole mass spectrometry.
2017 Nov
Patents

Patents

Sample Use Guides

In Vivo Use Guide
10 mg/kg per injection, with a maximum treatment of 10 injections
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:55:45 GMT 2023
Edited
by admin
on Fri Dec 15 18:55:45 GMT 2023
Record UNII
5X1442L8IO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOLDIMFOS
INN   WHO-DD  
INN  
Official Name English
PHOSPHIJET
Brand Name English
PHOSPHINIC ACID, P-(4-(DIMETHYLAMINO)-2-METHYLPHENYL)-
Common Name English
(4-(DIMETHYLAMINO)-O-TOLYL)PHOSPHINIC ACID
Common Name English
toldimfos [INN]
Common Name English
Toldimfos [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78276
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
WHO-VATC QA12CX90
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
Code System Code Type Description
PUBCHEM
68468
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
INN
2811
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105341
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
RXCUI
2001181
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
EVMPD
SUB11153MIG
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
CAS
57808-64-7
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID701224436
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
NCI_THESAURUS
C152680
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
FDA UNII
5X1442L8IO
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
SMS_ID
100000077753
Created by admin on Fri Dec 15 18:55:45 GMT 2023 , Edited by admin on Fri Dec 15 18:55:45 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY