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Details

Stereochemistry ACHIRAL
Molecular Formula C9H13NO2P.Na.3H2O
Molecular Weight 275.2144
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLDIMFOS SODIUM TRIHYDRATE

SMILES

O.O.O.[Na+].CN(C)C1=CC=C(C(C)=C1)P([O-])=O

InChI

InChIKey=BDGOJHYUVFGBMG-UHFFFAOYSA-M
InChI=1S/C9H14NO2P.Na.3H2O/c1-7-6-8(10(2)3)4-5-9(7)13(11)12;;;;/h4-6,13H,1-3H3,(H,11,12);;3*1H2/q;+1;;;/p-1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C9H14NO2P
Molecular Weight 199.1867
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Toldimfos is an aromatic phosphorus compound which falls between phosphorous itself and phosphoric acid in the stages of oxidation. Toldimfos sodium is the sodium salt of 2- methyl-4-(dimethylamino)phenylphosphinic acid. It is used to treat and prevent diseases associated with parturition and peri-partum period, developmental and nutritional disorders in young animals, and bone growth disorders and tetany or paresis caused by calcium, magnesium, and phosphorus metabolism disorders. Toldimfos has been used as a human medicine since 1920. While it is no longer indicated for human use, it is used in horses, cattle, sheep, pigs, and goats, and administered by intravenous, intramuscular, or subcutaneous injection. No specific data on the pharmacodynamic action of toldimfos was submitted. The precise mode of action of toldimfos is unknown and it is questionable whether the effect of toldimfos is simply a matter of the substitution of deficient phosphorus. It appears more likely that the effect of toldimfos arises due to multiple stimulation of metabolism with the body.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In Vivo Use Guide
10 mg/kg per injection, with a maximum treatment of 10 injections
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:46:11 GMT 2023
Edited
by admin
on Sat Dec 16 09:46:11 GMT 2023
Record UNII
W5ZL194O6T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOLDIMFOS SODIUM TRIHYDRATE
MI   WHO-DD  
Common Name English
TOLDIMFOS SODIUM TRIHYDRATE [MI]
Common Name English
PHOSPHINIC ACID, (4-(DIMETHYLAMINO)-2-METHYLPHENYL)-, SODIUM SALT, TRIHYDRATE
Common Name English
Toldimfos sodium trihydrate [WHO-DD]
Common Name English
P-DIMETHYLAMINO-O-TOLUENEPHOSPHONOUS ACID, SODIUM SALT, TRIHYDRATE
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID20360835
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY
FDA UNII
W5ZL194O6T
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY
MERCK INDEX
m10942
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY Merck Index
SMS_ID
100000084654
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY
CAS
5787-63-3
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY
EVMPD
SUB04907MIG
Created by admin on Sat Dec 16 09:46:11 GMT 2023 , Edited by admin on Sat Dec 16 09:46:11 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE