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Details

Stereochemistry ACHIRAL
Molecular Formula C2H8N2
Molecular Weight 60.0983
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Ethylenediamine

SMILES

NCCN

InChI

InChIKey=PIICEJLVQHRZGT-UHFFFAOYSA-N
InChI=1S/C2H8N2/c3-1-2-4/h1-4H2

HIDE SMILES / InChI
Molecular Formula C2H8N2
Molecular Weight 60.0983
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ethylenediamine is a strongly basic amine useful as a building block in chemical synthesis. It is used as a solvent to dissolve proteins such as albumins, casein and in medicine to stabilize aminophylline when used in injections. Ethylenediamine is used in manufacture of chelating agents (EDTA), epoxy curing agents, dimethylolethylene-urea resins, emulsifying agents, textile lubricants, antifreeze inhibitor. It is also involved in the manufacture of many industrial chemicals and forms derivatives with carboxylic acids, nitriles, alcohols, alkylating agents, carbon disulfide, aldehydes and ketones. It is a basic building block to prepare heterocyclic compound such as imidazolidines.

Approval Year

1979
65
PubMed

PubMed

TitleDatePubMed
[Ph(2)Bi-(Ge(9))-BiPh(2)](2-): a deltahedral Zintl ion functionalized by exo-bonded ligands.
2002-03-20
Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues.
2002-03-19
Designed self-assembly of molecular necklaces.
2002-03-13
Three different bonding modes of cyano groups in the coordination polymer [Cu(en)2(H(2)O)][Cu(en)(2)Ni(2)Cu(2)(CN)(10)] x 2H(2)O (en is 1,2-diaminoethane).
2002-03
Development of preparation methods for and insights obtained from atomic force microscopy of fluid spaces in cortical bone.
2002-02-28
Structure-directing coordination template effect of ethylenediamine in formations of ZnS and ZnSe nanocrystallites via solvothermal route.
2002-02-25
c-erbB-2 is not a major factor in the development of colorectal cancer.
2002-02-12
Schiff bis bases: analytical reagents. II. Spectrophotometric determination of manganese from pharmaceutical forms.
2002-02-01
[Occupational asthma due to amines].
2002-02
Experimental studies on the nature of bonding of DNA*bipyridyl-(ethylenediamine)platinum(II) and DNA*netropsin complexes in solution and oriented wet-spun films.
2002-02
Bis(ethylenediamine)copper(II) bis(O,O'-diethyl dithiophosphate).
2002-02
Molecular characteristics of glnA linked mutations in the nitrogen-fixing cyanobacterium Nostoc muscorum.
2002-02
Direct synthesis of peptides on convective interaction media monolithic columns for affinity chromatography.
2002-01-16
Syntheses, crystal structures, and density functional theory calculations of the closo-[1-M(CO)(3)(eta(4)-E(9))](4-) (E = Sn, Pb; M = Mo, W) cluster anions and solution NMR spectroscopic characterization of [1-M(CO)(3)(eta(4)-Sn(9))](4-) (M = Cr, Mo, W).
2002-01-14
Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum.
2002-01-02
Gramicidin derivatives as membrane-based pH sensors.
2002-01-02
Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.
2002-01
Optimization of urease immobilization onto non-porous HEMA incorporated poly(EGDMA) microbeads and estimation of kinetic parameters.
2002-01
Galactosylated alginate as a scaffold for hepatocytes entrapment.
2002-01
Secretion of a trypsin-like thiol protease by a new keratinolytic strain of Bacillus licheniformis.
2001-12-18
Enzymatic properties of sialic acid binding lectin from Rana catesbeiana modified with a water-soluble carbodiimide in the presence of various nucleophiles.
2001-12
Plane-wave density functional theoretic study of formation of clay-polymer nanocomposite materials by self-catalyzed in situ intercalative polymerization.
2001-11-28
[[Cu(en)(2)](2)Re(4)Te(4)(CN)(12)].5H(2)O and [[Cu(en)(2)](2)Re(6)Te(8)(CN)(6)].5H(2)O: bonding of a transition-metal complex to a rhenium chalcocyanide cluster.
2001-11-19
Gold-gold interactions as crystal engineering design elements in heterobimetallic coordination polymers.
2001-11-05
A three-dimensional porous framework complex, poly[[bis(ethylenediamine)copper(II)] [potassium hexacyanocobalt(III)]].
2001-11
Layered cobalt hydroxysulfates with both rigid and flexible organic pillars: synthesis, structure, porosity, and cooperative magnetism.
2001-10-31
Inhibition of cancer cell growth by ruthenium(II) arene complexes.
2001-10-25
The effect of pH and concentration upon aggregation transitions in aqueous solutions of poloxamine T701.
2001-10-23
[Effect of alpha-lipoic acid preparations on bilirubin and transferrin levels and ferritin iron and transferrin iron content].
2001-10-20
Synthesis and antifungal activity of 3,3'-ethylenebis(5-alkyl-1,3,5-thiadiazine-2-thiones).
2001-10
Polar nitrogen compounds and their behaviour in the drinking water treatment process.
2001-10
Predictive value of chromatin decondensation in vitro on fertilization rate after intracytoplasmic sperm injection (ICSI).
2001-10
Syntheses, vibrational spectra, and theoretical studies of the adamantanoid Sn(4)Ch(10)(4-) (Ch = Se, Te) anions: X-ray crystal structures of [18-crown-6-K](4)[Sn4Se10]*5en and [18-crown-6-K](4)[Sn4Te10]*3en*2THF.
2001-09-10
Design of oxytocin antagonists, which are more selective than atosiban.
2001-09
Effect of modification of the carboxyl groups of the sialic acid binding lectin from bullfrog (Rana catesbeiana) oocyte on anti-tumor activity.
2001-09
Aminoethylethanolamine: a new allergen in cosmetics?
2001-09
Synthesis and structure of [K(+)-(2,2)diaza-[18]-crown-6][K3Ge9]-2ethylenediamine: stabilization of the two-dimensional layer (2)(infinity)[K3Ge9(1-)].
2001-08-27
Prenatal HLA typing of uncultured amniocytes prior to the collection of related allogeneic cord blood.
2001-08
Speciation of rare earth elements in soil by sequential extraction then HPLC coupled with visible and ICP-MS detection.
2001-08
Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): monomeric and dimeric 1:1 adducts with 1,2-bis(4-pyridyl)ethane and 1,2-diaminoethane.
2001-08
[H3N(CH2)2NH3]0.5[BePO4], a beryllophosphate analogue of aluminosilicate zeolite gismondine.
2001-08
[Effect of calcium ion level in blood on physiological functions in rat subjected to immersion hypothermia].
2001-07
Rabbit M cells and dome enterocytes are distinct cell lineages.
2001-06
Use of a new HemoCue system for measuring haemoglobin at low concentrations.
2001-04
Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part II. Synthesis and configuration of (1,2-diaminoethane)bis(L-tyrosinato)cobalt(III)complex diastereomers. The crystal structure of the delta-C1-cis(O) diastereomer.
2001
Utilization of quinolone drugs as monomers: characterization of the synthesis reaction products for poly(norfloxacin diisocyanatododecane polycaprolactone).
2001
Yield and post-yield behavior of mussel byssal thread: a self-healing biomolecular material.
2001
Kinetics and mechanisms of EDTA photocatalytic degradation with TiO2.
2001
[Effect of Na2H2EDTA on the viability of rats' organism during hypothermia].
2001
Non-detection of Chlamydia species in carotid atheroma using generic primers by nested PCR in a population with a high prevalence of Chlamydia pneumoniae antibody.
2001
Patents

Patents

03960980
5
03994920
6
04008272
5
04060639
5
04062798
6
04062864
8
04096276
6
04100300
5
04119668
13
04168214
7
04197305
5
04206217
10
04211878
5
04212762
5
04228291
16
04254056
16
04260632
5
04318921
5
04327113
5
04346111
5
04364875
6
04366156
7
04386220
5
04421578
5
04443602
7
04598079
15
04659725
9
04709032
5
04725283
6
04734415
7
04886622
5
04889855
5
04904675
6
04906661
5
04910341
6
04935420
8
05073629
7
05096904
5
05097045
6
05103041
5
05126448
7
05138064
7
05140031
5
05204352
5
05204360
6
05225597
5
05227474
5
05245047
6
05270464
5
05298507
6
05371079
9
05486603
6
05490866
5
05543559
5
05610165
5
05610174
7
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:33:06 GMT 2025
Edited
by admin
on Mon Mar 31 17:33:06 GMT 2025
Record UNII
60V9STC53F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Ethylenediamine
EP   HSDB   II   MART.   MI   USP   WHO-DD  
Systematic Name English
EDAMINE
INN  
INN  
Preferred Name English
ETHYLENEDIAMINE [MART.]
Common Name English
ETHYLENE DIAMINE
Common Name English
ETHYLENEDIAMINE [HSDB]
Common Name English
ETHYLENEDIAMINE [II]
Common Name English
ETHYLENEDIAMINE [EP MONOGRAPH]
Common Name English
Ethylenediamine [WHO-DD]
Common Name English
1,2-DIAMINOETHANE
Systematic Name English
1,2-ETHANEDIAMINE
Systematic Name English
ETHYLENEDIAMINE [JAN]
Common Name English
edamine [INN]
Common Name English
ETHYLENEDIAMINE [USP MONOGRAPH]
Common Name English
PB05721
Code English
ETHYLENEDIAMINE [MI]
Common Name English
TIZANIDINE HYDROCHLORIDE IMPURITY H [EP IMPURITY]
Common Name English
PB-05721
Code English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
EPA PESTICIDE CODE 4205
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
CFR 21 CFR 173.320
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
Code System Code Type Description
RXCUI
4158
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY RxNorm
INN
7141
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
NDF-RT
N0000171131
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY Allergens [Chemical/Ingredient]
MERCK INDEX
m5119
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY Merck Index
DRUG BANK
DB14189
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
ChEMBL
CHEMBL816
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
CONCEPT Industrial Aid
PUBCHEM
3301
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
FDA UNII
60V9STC53F
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
ECHA (EC/EINECS)
203-468-6
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
CHEBI
30347
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
EVMPD
SUB13760MIG
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
CAS
107-15-3
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
WIKIPEDIA
ETHYLENEDIAMINE
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
DAILYMED
60V9STC53F
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
NDF-RT
N0000184306
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY Cell-mediated Immunity [PE]
EPA CompTox
DTXSID5021881
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
NCI_THESAURUS
C80898
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
SMS_ID
100000092194
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
HSDB
535
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY
NDF-RT
N0000175629
Created by admin on Mon Mar 31 17:33:06 GMT 2025 , Edited by admin on Mon Mar 31 17:33:06 GMT 2025
PRIMARY Increased Histamine Release [PE]
Related Record Type Details
Structure of AMINOPHYLLINE DIHYDRATE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE THIOCTATE
SALT/SOLVATE -> PARENT
Structure of ENRASENTAN EDAMINE
SALT/SOLVATE -> PARENT
Structure of FOSFOMYCIN ETHYLENEDIAMINE MONOBASIC
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE DIHYDRIODIDE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE SULFATE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE MONOHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE MANDELATE
SALT/SOLVATE -> PARENT
Structure of POBILUKAST EDAMINE
SALT/SOLVATE -> PARENT
Structure of ETHYLENEDIAMINE MONOHYDRATE
SOLVATE->ANHYDROUS
Structure of AMINOPHYLLINE MONOHYDRATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of Nilotinib hydrochloride monohydrate
PARENT -> IMPURITY
Structure of TIZANIDINE HYDROCHLORIDE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (TLC)
EP
Related Record Type Details
Structure of Ethylenediamine
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