Ethylenediamine

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H8N2
Molecular Weight	60.0983
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCN

InChI

InChIKey=PIICEJLVQHRZGT-UHFFFAOYSA-N

InChI=1S/C2H8N2/c3-1-2-4/h1-4H2

HIDE SMILES / InChI

Molecular Formula	C2H8N2
Molecular Weight	60.0983
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.measurement.gov.au/Services/Documents/SafetyDataSheets/Ethylenediamine-preservative-for-Chlorite-Samples.pdf | https://www.alfa.com/en/catalog/A12132/

Ethylenediamine is a strongly basic amine useful as a building block in chemical synthesis. It is used as a solvent to dissolve proteins such as albumins, casein and in medicine to stabilize aminophylline when used in injections. Ethylenediamine is used in manufacture of chelating agents (EDTA), epoxy curing agents, dimethylolethylene-urea resins, emulsifying agents, textile lubricants, antifreeze inhibitor. It is also involved in the manufacture of many industrial chemicals and forms derivatives with carboxylic acids, nitriles, alcohols, alkylating agents, carbon disulfide, aldehydes and ketones. It is a basic building block to prepare heterocyclic compound such as imidazolidines.

Approval Year

PubMed

Title	Date	PubMed
[Effect of Na2H2EDTA on the viability of rats' organism during hypothermia].	2001	11668962
Non-detection of Chlamydia species in carotid atheroma using generic primers by nested PCR in a population with a high prevalence of Chlamydia pneumoniae antibody.	2001	11553320
Synthesis, evaluation and structure-activity relationships of 5-alkyl-2,3-dihydroimidazo[1,2-c] quinazoline, 2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-thiones and their oxo-analogues as new potential bronchodilators.	2001	11367868
Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome.	2001	11353932
Reduction of dioxygen by a dimanganese unit bonded inside a cavity provided by a pyrrole-based dinucleating ligand.	2001 Apr 1	11330901
Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): monomeric and dimeric 1:1 adducts with 1,2-bis(4-pyridyl)ethane and 1,2-diaminoethane.	2001 Aug	11498611
[H3N(CH2)2NH3]0.5[BePO4], a beryllophosphate analogue of aluminosilicate zeolite gismondine.	2001 Aug	11498602
Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate.	2001 Aug	11340591
Synthesis and structure of [K(+)-(2,2)diaza-[18]-crown-6][K3Ge9]-2ethylenediamine: stabilization of the two-dimensional layer (2)(infinity)[K3Ge9(1-)].	2001 Aug 27	11511221
Enzymatic properties of sialic acid binding lectin from Rana catesbeiana modified with a water-soluble carbodiimide in the presence of various nucleophiles.	2001 Dec	11767103
Synthesis of 1-(3-aminopropyl)-4-phenyl-1,2,4-triazolin-5-one and 1-(3-aminopropyl)-3,4-diphenyl-1,2,4-triazolin-5-one.	2001 Jan-Feb	11370286
Behaviour of 2-substituted 1,3-indandiones towards aldimines.	2001 Jan-Feb	11338778
[Effect of calcium ion level in blood on physiological functions in rat subjected to immersion hypothermia].	2001 Jul	11575127
Preparation of a ribonucleic acid-(polyamidoamine)-(zirconia-urea-formaldehyde resin) high-performance liquid affinity chromatographic stationary phase.	2001 Jul	11471990
Ion chromatographic determination of calcium and magnesium cations in human saliva and urine with a piezoelectric detector.	2001 Jul	11377089
An HPTLC method for the determination and the purity control of ciprofloxacin HCl in coated tablets.	2001 Jul	11377079
catena-Poly[dibromozinc(II)-mu-ethylenediamine-N:N']: resolution of structural anomalies resulting from the interpretation of vibrational spectra.	2001 Jun	11408665
Solid-phase synthesis of chiral stationary phases based on 2,4,5,6-tetrachloro-1,3-dicyanobenzene derivatives spaced from N-3,5-dinitrobenzoyl alpha-amino acids: comparative study of their resolution efficacy.	2001 Jun	11370018
Isolation and identification of clozapine metabolites in patient urine.	2001 Jun	11353764
Biodegradability of ethylenediamine-based complexing agents.	2001 Jun	11337848
Development of an ELISA to measure soluble CD163 in biological fluids.	2001 Jun 1	11334962
Chromium-51 ethylenediamine tetraacetic acid glomerular filtration rate: a better predictor than glomerular filtration rate calculated by the Cockcroft-Gault formula for renal involvement in systemic lupus erythematosus patients.	2001 Mar	11285381
Rb(4)Hg(5)(Te(2))(2)(Te(3))(2)Te(3), [Zn(en)3](4)In(16)(Te2)4(Te3)Te22, and K2Cu2(Te2)(Te3): novel metal polytellurides with unusual metal-tellurium coordination.	2001 Mar 12	11300839
Structures of a tetradentate ferrocenyl ligand and its oxorhenium(V) complex in solution and in the solid state.	2001 Mar 12	11300819
Macrochelation, cyclometallation and G-quartet formation: N3- and C8-bound PdII complexes of adenine and guanine.	2001 Mar 16	11322545
Chemoenzymatic synthesis of sucrose-containing aromatic polymers.	2001 Mar 5	11460244
Chirality inversion in the bilirubin molecular exciton.	2001 May 15	11317346
Template synthesis of a tetraazamacrocyclic ligand with two pendant pyridinyl groups: properties of the isomers of the metal-free ligand and of their first-row transition metal compounds.	2001 May 7	11327910
Plane-wave density functional theoretic study of formation of clay-polymer nanocomposite materials by self-catalyzed in situ intercalative polymerization.	2001 Nov 28	11716733
Gold-gold interactions as crystal engineering design elements in heterobimetallic coordination polymers.	2001 Nov 5	11681921
Synthesis and antifungal activity of 3,3'-ethylenebis(5-alkyl-1,3,5-thiadiazine-2-thiones).	2001 Oct	11759168
Polar nitrogen compounds and their behaviour in the drinking water treatment process.	2001 Oct	11561612
Predictive value of chromatin decondensation in vitro on fertilization rate after intracytoplasmic sperm injection (ICSI).	2001 Oct	11554990
Effect of modification of the carboxyl groups of the sialic acid binding lectin from bullfrog (Rana catesbeiana) oocyte on anti-tumor activity.	2001 Sep	11558580
Aminoethylethanolamine: a new allergen in cosmetics?	2001 Sep	11553136
Syntheses, vibrational spectra, and theoretical studies of the adamantanoid Sn(4)Ch(10)(4-) (Ch = Se, Te) anions: X-ray crystal structures of [18-crown-6-K](4)[Sn4Se10]5en and [18-crown-6-K](4)[Sn4Te10]3en*2THF.	2001 Sep 10	11531427
[Occupational asthma due to amines].	2002 Feb	11844442
c-erbB-2 is not a major factor in the development of colorectal cancer.	2002 Feb 12	11870539
Structure-directing coordination template effect of ethylenediamine in formations of ZnS and ZnSe nanocrystallites via solvothermal route.	2002 Feb 25	11849088
Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.	2002 Jan	11786281
Optimization of urease immobilization onto non-porous HEMA incorporated poly(EGDMA) microbeads and estimation of kinetic parameters.	2002 Jan	11762905
Galactosylated alginate as a scaffold for hepatocytes entrapment.	2002 Jan	11761168
Syntheses, crystal structures, and density functional theory calculations of the closo-[1-M(CO)(3)(eta(4)-E(9))](4-) (E = Sn, Pb; M = Mo, W) cluster anions and solution NMR spectroscopic characterization of [1-M(CO)(3)(eta(4)-Sn(9))](4-) (M = Cr, Mo, W).	2002 Jan 14	11782147
Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum.	2002 Jan 2	11755170
Development of preparation methods for and insights obtained from atomic force microscopy of fluid spaces in cortical bone.	2002 Jan-Feb	11866342
Direct synthesis of peptides on convective interaction media monolithic columns for affinity chromatography.	2002 Jan-Feb	11790136
Three different bonding modes of cyano groups in the coordination polymer [Cu(en)2(H(2)O)][Cu(en)(2)Ni(2)Cu(2)(CN)(10)] x 2H(2)O (en is 1,2-diaminoethane).	2002 Mar	11870291
Designed self-assembly of molecular necklaces.	2002 Mar 13	11878967
Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues.	2002 Mar 19	11888302
[Ph(2)Bi-(Ge(9))-BiPh(2)](2-): a deltahedral Zintl ion functionalized by exo-bonded ligands.	2002 Mar 20	11890785

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:33:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:33:06 GMT 2025`
Record UNII	60V9STC53F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ethylenediamine

Systematic Name

English

EDAMINE

Preferred Name

English

ETHYLENEDIAMINE [MART.]

Common Name

English

ETHYLENE DIAMINE

Common Name

English

ETHYLENEDIAMINE [HSDB]

Common Name

English

ETHYLENEDIAMINE [II]

Common Name

English

ETHYLENEDIAMINE [EP MONOGRAPH]

Common Name

English

Ethylenediamine [WHO-DD]

Common Name

English

1,2-DIAMINOETHANE

Systematic Name

English

1,2-ETHANEDIAMINE

Systematic Name

English

ETHYLENEDIAMINE [JAN]

Common Name

English

edamine [INN]

Common Name

English

ETHYLENEDIAMINE [USP MONOGRAPH]

Common Name

English

PB05721

Code

English

ETHYLENEDIAMINE [MI]

Common Name

English

TIZANIDINE HYDROCHLORIDE IMPURITY H [EP IMPURITY]

Common Name

English

PB-05721

Code

English

Classification Tree Code System Code

NDF-RT

N0000185508