OXSI-2

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H15N3O3S
Molecular Weight	353.395
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=C(\C=C2/C(=O)NC3=C2C=C(C=C3)S(N)(=O)=O)C4=C1C=CC=C4

InChI

InChIKey=MLKHXLFEYOOYEY-NVNXTCNLSA-N

InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-

HIDE SMILES / InChI

Molecular Formula	C18H15N3O3S
Molecular Weight	353.395
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosine-protein kinase SYK 21 Target ID: CHEMBL2599 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12941345 \| https://www.ncbi.nlm.nih.gov/pubmed/22257213	Inhibitor 8297		14.0 nM [IC50]

PubMed

Title	Date	PubMed
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).	2003 Sep 15	12941345
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.	2012 Apr 26	22257213

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:08:21 GMT 2023` Edited by `admin` on `Sat Dec 16 11:08:21 GMT 2023`
Record UNII	5YZ3QBQ97C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXSI-2

Code

English

SYK INHIBITOR

Common Name

English

K00564A

Code

English

CG-103065

Code

English

SPLEEN TYROSINE KINASE INHIBITOR

Common Name

English

1H-INDOLE-5-SULFONAMIDE, 2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-

Systematic Name

English

2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-1H-INDOLE-5-SULFONAMIDE

Systematic Name

English

1H-INDOLE-5-SULFONAMIDE, 2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-, (3Z)-

Systematic Name

English

Code System Code Type Description

CHEBI

76617