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Details

Stereochemistry ACHIRAL
Molecular Formula C18H15N3O3S
Molecular Weight 353.3968
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of OXSI-2

SMILES

Cn1cc(/C(/[H])=C\2/c3cc(ccc3N=C2O)S(=O)(=O)N)c4ccccc41

InChI

InChIKey=MLKHXLFEYOOYEY-NVNXTCNLSA-N
InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-

HIDE SMILES / InChI

Molecular Formula C18H15N3O3S
Molecular Weight 353.3968
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
14.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
2003 Sep 15
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
2012 Apr 26
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:05:50 UTC 2021
Edited
by admin
on Sat Jun 26 08:05:50 UTC 2021
Record UNII
5YZ3QBQ97C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXSI-2
Code English
SYK INHIBITOR
Common Name English
K00564A
Code English
CG-103065
Code English
SPLEEN TYROSINE KINASE INHIBITOR
Common Name English
1H-INDOLE-5-SULFONAMIDE, 2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-
Systematic Name English
2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-1H-INDOLE-5-SULFONAMIDE
Systematic Name English
1H-INDOLE-5-SULFONAMIDE, 2,3-DIHYDRO-3-((1-METHYL-1H-INDOL-3-YL)METHYLENE)-2-OXO-, (3Z)-
Systematic Name English
Code System Code Type Description
CAS
1956296-96-0
Created by admin on Sat Jun 26 08:05:50 UTC 2021 , Edited by admin on Sat Jun 26 08:05:50 UTC 2021
PRIMARY
PUBCHEM
6419747
Created by admin on Sat Jun 26 08:05:50 UTC 2021 , Edited by admin on Sat Jun 26 08:05:50 UTC 2021
PRIMARY
CAS
622387-85-3
Created by admin on Sat Jun 26 08:05:50 UTC 2021 , Edited by admin on Sat Jun 26 08:05:50 UTC 2021
NON-SPECIFIC STEREOCHEMISTRY
FDA UNII
5YZ3QBQ97C
Created by admin on Sat Jun 26 08:05:50 UTC 2021 , Edited by admin on Sat Jun 26 08:05:50 UTC 2021
PRIMARY
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