C-X-C CHEMOKINE RECEPTOR TYPE 2

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:46:15 GMT 2025` Edited by `admin` on `Tue Apr 01 16:46:15 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	5Y2J7NY7SF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

C-X-C CHEMOKINE RECEPTOR TYPE 2

Common Name

English

CXCR-2

Preferred Name

English

CXCR2

Common Name

English

INTERLEUKIN 8 RECEPTOR, BETA

Common Name

English

IL8RB

Common Name

English

IL-8RB

Common Name

English

IL-8 RECEPTOR B

Common Name

English

GRO/MGSA RECEPTOR

Common Name

English

Code System Code Type Description

FDA UNII

5Y2J7NY7SF

Created by admin on Tue Apr 01 16:46:15 GMT 2025 , Edited by admin on Tue Apr 01 16:46:15 GMT 2025

PRIMARY

UNIPROT

P25025

Created by admin on Tue Apr 01 16:46:15 GMT 2025 , Edited by admin on Tue Apr 01 16:46:15 GMT 2025

PRIMARY

PHAROS

P25025

Created by admin on Tue Apr 01 16:46:15 GMT 2025 , Edited by admin on Tue Apr 01 16:46:15 GMT 2025

PRIMARY

From	To
1_119	1_196

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_22

Related Record Type Details


					4GMU5HUX5I

Navarixin anhydrous

INHIBITOR -> TARGET

Amount:


					MW2AIJ8USP

ELUBRIXIN

INHIBITOR -> TARGET

Amount:


					DEH7Q6472O

LADARIXIN

INHIBITOR -> TARGET

Amount:


					8PD78CVU5V

AZD-8309

INHIBITOR -> TARGET

Amount:


					X88GCV5DSA

WEAK INHIBITOR->TARGET

Qualification:

Kd

Amount:


					U604E1NB3K

REPARIXIN

INHIBITOR -> TARGET

Comments:

NONCOMPETIVE

Interaction Type:

ALLOSTERIC INHIBITOR

Qualification:

IC50

Amount:


					R318PGH5VP

DANIRIXIN

INHIBITOR -> TARGET

Amount:


					5KT86HK4WX

AZD-5122

INHIBITOR -> TARGET

Amount:


					4ADT8JXB9S

AZD-5069

INHIBITOR -> TARGET


					PC30892LX5

INHIBITOR -> TARGET

Comments:

Binding Assay

Qualification:

IC50

Amount:


					X09ORN2BF0

INHIBITOR -> TARGET

Interaction Type:

IN-VITRO

Amount:


					36UH926WTQ

SX-517

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_347] [1_351] [1_352] [1_353]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL