U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H23F2N5O4S2
Molecular Weight 475.533
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-5122

SMILES

C[C@@H](NC1=CC(NS(=O)(=O)N2CCC2)=NC(SCC3=C(F)C(F)=CC=C3)=N1)[C@@H](O)CO

InChI

InChIKey=QVKPEMXUBULFBM-RISCZKNCSA-N
InChI=1S/C18H23F2N5O4S2/c1-11(14(27)9-26)21-15-8-16(24-31(28,29)25-6-3-7-25)23-18(22-15)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,26-27H,3,6-7,9-10H2,1H3,(H2,21,22,23,24)/t11-,14+/m1/s1

HIDE SMILES / InChI
Molecular Formula C18H23F2N5O4S2
Molecular Weight 475.533
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

It is known, that SRT3109 is a ligand of CXCR2 for use in the treatment of chemokine mediated diseases and conditions. Others information is not available.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Interacts
323
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Patents

Patents

US2010016275
1
US2015210655
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 18:53:54 GMT 2023
Edited
by admin
on Sat Dec 16 18:53:54 GMT 2023
Record UNII
5KT86HK4WX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD-5122
Code English
SRT3109
Code English
AZD 5122 [WHO-DD]
Common Name English
SRT-3109
Code English
N-(2-(((2,3-DIFLUOROPHENYL)METHYL)THIO)-6-(((1R,2R)-2,3-DIHYDROXY-1-METHYLPROPYL)AMINO)-4-PYRIMIDINYL)-1-AZETIDINESULFONAMIDE
Systematic Name English
AZD5122
Code English
1-AZETIDINESULFONAMIDE, N-(2-(((2,3-DIFLUOROPHENYL)METHYL)THIO)-6-(((1R,2R)-2,3-DIHYDROXY-1-METHYLPROPYL)AMINO)-4-PYRIMIDINYL)-
Systematic Name English
Code System Code Type Description
CAS
1204707-71-0
Created by admin on Sat Dec 16 18:53:54 GMT 2023 , Edited by admin on Sat Dec 16 18:53:54 GMT 2023
PRIMARY
EPA CompTox
DTXSID80659631
Created by admin on Sat Dec 16 18:53:54 GMT 2023 , Edited by admin on Sat Dec 16 18:53:54 GMT 2023
PRIMARY
PUBCHEM
44602493
Created by admin on Sat Dec 16 18:53:54 GMT 2023 , Edited by admin on Sat Dec 16 18:53:54 GMT 2023
PRIMARY
FDA UNII
5KT86HK4WX
Created by admin on Sat Dec 16 18:53:54 GMT 2023 , Edited by admin on Sat Dec 16 18:53:54 GMT 2023
PRIMARY
Related Record Type Details
C-X-C CHEMOKINE RECEPTOR TYPE 2
TARGET -> INHIBITOR
Related Record Type Details
Structure of AZD-5122
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966