AZD-5069

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H22F2N4O5S2
Molecular Weight	476.518
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](OC1=NC(SCC2=CC=CC(F)=C2F)=NC(NS(=O)(=O)N3CCC3)=C1)[C@@H](O)CO

InChI

InChIKey=QZECRCLSIGFCIO-RISCZKNCSA-N

InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22-16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H,21,22,23)/t11-,14+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H22F2N4O5S2
Molecular Weight	476.518
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C-C chemokine receptor type 2 19 Target ID: CHEMBL4015 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29493096	Antagonist 2849
Interleukin-8 receptor B 10 Target ID: CHEMBL2434 Sources: https://patents.google.com/patent/WO2010007427A1	Antagonist 2849		8.2 null [pIC50]

C_max

Value	Dose	Analyte	Population
7.63 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
34.6 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.5 mg single, oral dose: 0.5 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
162 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	1.65 mg single, oral dose: 1.65 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
421 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	5.45 mg single, oral dose: 5.45 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1010 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	17.99 mg single, oral dose: 17.99 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4260 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
8070 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11900 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
760.99 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
770 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg 2 times / day multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
767 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg 2 times / day multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2210 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2470 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2180 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
5280 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
6950 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8360 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8440 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4190 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

AUC

Value	Dose	Analyte	Population
21.8 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
95.1 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.5 mg single, oral dose: 0.5 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
495 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	1.65 mg single, oral dose: 1.65 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1530 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	5.45 mg single, oral dose: 5.45 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4400 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	17.99 mg single, oral dose: 17.99 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
21000 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
37100 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
69900 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2260 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2270 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg 2 times / day multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2140 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg 2 times / day multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8390 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
9030 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8500 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
27280 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
29110 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
30100 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
35900 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
32400 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

T_1/2

Value	Dose	Analyte	Population
1.52 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1.72 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	0.5 mg single, oral dose: 0.5 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.84 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	1.65 mg single, oral dose: 1.65 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.93 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	5.45 mg single, oral dose: 5.45 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
10.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	17.99 mg single, oral dose: 17.99 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
10.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	60 mg single, oral dose: 60 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7.55 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.33 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
8.48 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	10 mg 2 times / day multiple, oral dose: 10 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4.12 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
10.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4.75 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4.75 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
9.93 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
9.91 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
8.76 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29856004/	120 mg single, oral dose: 120 mg route of administration: Oral experiment type: SINGLE co-administered:	AZD-5069 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

F_unbound

Value	Dose	Co-administered	Analyte	Population
99% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31113795/	unknown, unknown		AZD-5069 plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:00:33 GMT 2025` Edited by `admin` on `Mon Mar 31 21:00:33 GMT 2025`
Record UNII	4ADT8JXB9S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-(2-(((2,3-DIFLUOROPHENYL)METHYL)THIO)-6-(((1R,2S)-2,3-DIHYDROXY-1-METHYLPROPYL)OXY)-4-PYRIMIDINYL)-1-AZETIDINESULFONAMIDE

Preferred Name

English

AZD-5069

Code

English

AZD 5069 [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

4ADT8JXB9S