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Details

Stereochemistry ACHIRAL
Molecular Formula C9H7NO
Molecular Weight 145.1583
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXYQUINOLINE

SMILES

c1cc2cccnc2c(c1)O

InChI

InChIKey=MCJGNVYPOGVAJF-UHFFFAOYSA-N
InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

HIDE SMILES / InChI

Molecular Formula C9H7NO
Molecular Weight 145.1583
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including: http://www.cosmeticsinfo.org/ingredient/benzoxiquine-0

In cosmetics and personal care products, Benzoxiquine has been reported to be used in the formulation of hair tonics, dressings, and other hair grooming aids. Benzoxiquine is described as a biocide for use in cosmetic products. It is currently reported to be used in only one product. In a separate finding, the Food and Drug Administration determined that Benzoxiquine is not generally recognized as safe and effective in over-the-counter topical antifungal drug products. The only data available on the toxicity of Benzoxiquine indicates that it is mutagenic in the Ames test without metabolic activation. Because of the lack of data, the safety of Benzoxiquine could not be substantiated. The data needed to make a safety assessment include purity/impurities, ultraviolet absorption (if there is absorption, then photosensitization data will be needed), 28-day dermal toxicity, dermal teratogenicity, ocular irritation (if already available only), dermal irritation and sensitization, and two different genotoxicity studies (one using a mammalian system). If the latter data are positive, dermal carcinogenesis data using the methods of the National Toxicology Program will be needed. It cannot be concluded that Benzoxiquine is safe for use in cosmetic products until these safety data have been obtained and evaluated.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
In vitro studies of the antibacterial and antifungal activity of oxine and its derivatives.
1994 Aug
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
2013 Mar 28
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:23:40 UTC 2021
Edited
by admin
on Sat Jun 26 08:23:40 UTC 2021
Record UNII
5UTX5635HP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXYQUINOLINE
HSDB   II   INCI   USAN   VANDF  
USAN   INCI  
Official Name English
NSC-82405
Code English
NSC-82412
Code English
OXYQUINOL
Common Name English
NSC-615011
Code English
OXYQUINOLINE [HSDB]
Common Name English
HYDROXYQUINOLINE [WHO-DD]
Common Name English
NSC-82409
Code English
OXYQUINOLINE [II]
Common Name English
NSC-285166
Code English
8-HYDROXYQUINOLINE [MI]
Common Name English
HYDROXYQUINOLINE
VANDF   WHO-DD  
Systematic Name English
OXYQUINOLINE [USAN]
Common Name English
J2.960B
Code English
NSC-82404
Code English
8-HYDROXYQUINOLINE [IARC]
Common Name English
OXINE
Common Name English
8-HYDROXYQUINOLINE
MI  
Systematic Name English
NSC-402623
Code English
8-QUINOLINOL
Systematic Name English
OXYQUINOLINE [VANDF]
Common Name English
NSC-82410
Code English
NSC-48037
Code English
NSC-54230
Code English
OXYQUINOLINE [INCI]
Common Name English
NSC-2039
Code English
HYDROXYQUINOLINE [VANDF]
Common Name English
Classification Tree Code System Code
WHO-VATC QG01AC30
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
EPA PESTICIDE CODE 59803
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-ATC D08AH03
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
NCI_THESAURUS C28394
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-ATC G01AC30
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-ATC A01AB07
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-ATC R02AA14
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-VATC QR02AA14
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-VATC QD08AH03
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
WHO-VATC QA01AB07
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
Code System Code Type Description
RXCUI
110
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY RxNorm
EVMPD
SUB25866
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
HSDB
4073
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
EPA CompTox
148-24-3
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
ECHA (EC/EINECS)
205-711-1
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
MESH
D015125
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
EVMPD
SUB55720
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
NCI_THESAURUS
C80862
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
ChEMBL
CHEMBL310555
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
EVMPD
SUB14149MIG
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
CAS
148-24-3
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
DRUG BANK
DB11145
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
PUBCHEM
1923
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
WIKIPEDIA
8-HYDROXYQUINOLINE
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
DRUG CENTRAL
3290
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
MERCK INDEX
M6151
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY Merck Index
FDA UNII
5UTX5635HP
Created by admin on Sat Jun 26 08:23:41 UTC 2021 , Edited by admin on Sat Jun 26 08:23:41 UTC 2021
PRIMARY
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