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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H21F2N3O
Molecular Weight 345.3871
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEDALINAB

SMILES

CC(C)(C)N=C(c1c2[C@@]3([H])CC[C@]([H])(C3)c2n(-c4ccc(cc4F)F)n1)O

InChI

InChIKey=NTPZXHMTJGOMCJ-WDEREUQCSA-N
InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1

HIDE SMILES / InChI

Molecular Formula C19H21F2N3O
Molecular Weight 345.3871
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Glenmark Pharmaceuticals has developed tedalinab (also known as GRC-10693) as a potent and selective cannabinoid CB2 receptor agonist for the treatment of osteoarthritis and neuropathic pain. In April 2009, Glenmark announced that tedalinab indicated for the treatment of neuropathic, osteoarthritis and other inflammatory pain disorders had successfully completed Phase I trials in Europe. The drug was ready for phase II of trials; however, information about the further development of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
The Drug Discovery and Development Industry in India-Two Decades of Proprietary Small-Molecule R&D.
2017 Jun 7
Patents

Sample Use Guides

300 mg of GRC 10693 (Tedalinab) once daily for 14 days
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:07:05 UTC 2021
Edited
by admin
on Sat Jun 26 07:07:05 UTC 2021
Record UNII
5R7X34Y6Q1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TEDALINAB
INN   WHO-DD  
INN  
Official Name English
GRC10693
Code English
GRC-10693
Code English
TEDALINAB [WHO-DD]
Common Name English
TEDALINAB [INN]
Common Name English
(4S,7R)-N-TERT-BUTYL-1-(2,4-DIFLUOROPHENYL)-4,5,6,7-TETRAHYDRO-1H-4,7-METHANOINDAZOLE-3-CARBOXAMIDE
Systematic Name English
4,7-METHANO-1H-INDAZOLE-3-CARBOXAMIDE, 1-(2,4-DIFLUOROPHENYL)-N-(1,1-DIMETHYLETHYL)-4,5,6,7-TETRAHYDRO-, (4S,7R)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
Code System Code Type Description
PUBCHEM
67029278
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
ChEMBL
CHEMBL3234681
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
INN
9257
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
WIKIPEDIA
Tedalinab
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
NCI_THESAURUS
C152534
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
FDA UNII
5R7X34Y6Q1
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
CAS
916591-01-0
Created by admin on Sat Jun 26 07:07:05 UTC 2021 , Edited by admin on Sat Jun 26 07:07:05 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
very high selectivity of 4700x for CB2 over the related CB1 receptor
Related Record Type Details
ACTIVE MOIETY