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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H21F2N3O
Molecular Weight 345.3863
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEDALINAB

SMILES

CC(C)(C)NC(=O)C1=NN(C2=C1[C@H]3CC[C@@H]2C3)C4=C(F)C=C(F)C=C4

InChI

InChIKey=NTPZXHMTJGOMCJ-WDEREUQCSA-N
InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1

HIDE SMILES / InChI

Molecular Formula C19H21F2N3O
Molecular Weight 345.3863
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Glenmark Pharmaceuticals has developed tedalinab (also known as GRC-10693) as a potent and selective cannabinoid CB2 receptor agonist for the treatment of osteoarthritis and neuropathic pain. In April 2009, Glenmark announced that tedalinab indicated for the treatment of neuropathic, osteoarthritis and other inflammatory pain disorders had successfully completed Phase I trials in Europe. The drug was ready for phase II of trials; however, information about the further development of this drug is not available.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
300 mg of GRC 10693 (Tedalinab) once daily for 14 days
Route of Administration: Oral
Substance Class Chemical
Record UNII
5R7X34Y6Q1
Record Status Validated (UNII)
Record Version