CIPROXIFAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H18N2O2
Molecular Weight	270.3263
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(C1CC1)C2=CC=C(OCCCC3=CN=CN3)C=C2

InChI

InChIKey=ACQBHJXEAYTHCY-UHFFFAOYSA-N

InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C16H18N2O2
Molecular Weight	270.3263
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 44 Target ID: CHEMBL4124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15115409 \| https://www.ncbi.nlm.nih.gov/pubmed/11052804 \| https://www.ncbi.nlm.nih.gov/pubmed/21366724	Antagonist 2778		0.49 nM [Ki]

PubMed

Title	Date	PubMed
Different antagonist binding properties of human and rat histamine H3 receptors.	2001 Apr 9	11294398
Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp.	2001 Jan	11163599
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists.	2001 Jun	11384847
Effect of BP 2.94, a histamine H3-receptor agonist prodrug, on different models of colitis.	2002 Apr	12013398
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.	2002 Jun	12175472
Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes.	2002 Nov	12372902
Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats.	2003 Sep 15	12946612
Effects of histamine H3 receptor antagonists in two models of spatial learning.	2005 Apr 30	15817192
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.	2007 Jan	17005916
Modulation of hippocampal theta oscillation by histamine H3 receptors.	2008 Jan	17940197
A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.	2008 Jun	18593375
11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET.	2009 Dec	19910432
Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists.	2010 Feb 1	19787776
Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice.	2010 Jan	19911169

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:52:44 GMT 2023` Edited by `admin` on `Sat Dec 16 09:52:44 GMT 2023`
Record UNII	5EVQ7IRG99
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CIPROXIFAN

Common Name

English

METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-5-YL)PROPOXY)PHENYL)-

Systematic Name

English

FUB-359

Code

English

METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-4-YL)PROPOXY)PHENYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

6422124