U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H18N2O2
Molecular Weight 270.3263
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIPROXIFAN

SMILES

O=C(C1CC1)C2=CC=C(OCCCC3=CN=CN3)C=C2

InChI

InChIKey=ACQBHJXEAYTHCY-UHFFFAOYSA-N
InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)

HIDE SMILES / InChI

Molecular Formula C16H18N2O2
Molecular Weight 270.3263
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Different antagonist binding properties of human and rat histamine H3 receptors.
2001 Apr 9
The rat H3 receptor: gene organization and multiple isoforms.
2001 Jan 12
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists.
2001 Jun
Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat.
2002 Aug 15
Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.
2002 Jan
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.
2002 Jun
Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat.
2002 May
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists.
2002 May
Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain.
2004 Aug
Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan.
2004 Aug 12
G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
2005 Jul
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs.
2005 May 31
A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.
2008 Jun
Comparison of the pharmacological properties of human and rat histamine H(3)-receptors.
2010 Nov 1
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
2015 Jul
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 09:52:44 UTC 2023
Edited
by admin
on Sat Dec 16 09:52:44 UTC 2023
Record UNII
5EVQ7IRG99
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIPROXIFAN
Common Name English
METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-5-YL)PROPOXY)PHENYL)-
Systematic Name English
FUB-359
Code English
METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-4-YL)PROPOXY)PHENYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
6422124
Created by admin on Sat Dec 16 09:52:44 UTC 2023 , Edited by admin on Sat Dec 16 09:52:44 UTC 2023
PRIMARY
EPA CompTox
DTXSID50171532
Created by admin on Sat Dec 16 09:52:44 UTC 2023 , Edited by admin on Sat Dec 16 09:52:44 UTC 2023
PRIMARY
CAS
184025-18-1
Created by admin on Sat Dec 16 09:52:44 UTC 2023 , Edited by admin on Sat Dec 16 09:52:44 UTC 2023
PRIMARY
FDA UNII
5EVQ7IRG99
Created by admin on Sat Dec 16 09:52:44 UTC 2023 , Edited by admin on Sat Dec 16 09:52:44 UTC 2023
PRIMARY
WIKIPEDIA
CIPROXIFAN
Created by admin on Sat Dec 16 09:52:44 UTC 2023 , Edited by admin on Sat Dec 16 09:52:44 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY