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Details

Stereochemistry ACHIRAL
Molecular Formula C16H18N2O2
Molecular Weight 270.3263
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIPROXIFAN

SMILES

O=C(C1CC1)C2=CC=C(OCCCC3=CN=CN3)C=C2

InChI

InChIKey=ACQBHJXEAYTHCY-UHFFFAOYSA-N
InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)

HIDE SMILES / InChI

Molecular Formula C16H18N2O2
Molecular Weight 270.3263
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat.
2002 Aug 15
Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.
2002 Feb
Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.
2002 Jan
Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain.
2002 Mar
Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat.
2002 May
Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa.
2002 Sep
Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control.
2002 Sep 1
Cloning and pharmacological characterization of the monkey histamine H3 receptor.
2003 Dec 15
Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization.
2003 Jun
Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms.
2004 Sep
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
2004 Sep 1
Effects of histamine H3 receptor antagonists in two models of spatial learning.
2005 Apr 30
N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain.
2006 Sep
The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.
2007 Apr 15
Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test.
2007 Apr 15
Modulation of hippocampal theta oscillation by histamine H3 receptors.
2008 Jan
A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.
2008 Jun
11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET.
2009 Dec
H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval.
2009 Jan
Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice.
2010 Jan
Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists.
2010 Jul
Antihistaminic drugs modify casein-induced inflammation in the rat.
2010 Mar
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
2015 Jul
Patents

Patents

Substance Class Chemical
Created
by admin
on Sun Dec 18 03:18:28 UTC 2022
Edited
by admin
on Sun Dec 18 03:18:28 UTC 2022
Record UNII
5EVQ7IRG99
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIPROXIFAN
Common Name English
METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-5-YL)PROPOXY)PHENYL)-
Systematic Name English
FUB-359
Code English
METHANONE, CYCLOPROPYL(4-(3-(1H-IMIDAZOL-4-YL)PROPOXY)PHENYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
6422124
Created by admin on Sun Dec 18 03:18:28 UTC 2022 , Edited by admin on Sun Dec 18 03:18:28 UTC 2022
PRIMARY
EPA CompTox
DTXSID50171532
Created by admin on Sun Dec 18 03:18:28 UTC 2022 , Edited by admin on Sun Dec 18 03:18:28 UTC 2022
PRIMARY
CAS
184025-18-1
Created by admin on Sun Dec 18 03:18:28 UTC 2022 , Edited by admin on Sun Dec 18 03:18:28 UTC 2022
PRIMARY
FDA UNII
5EVQ7IRG99
Created by admin on Sun Dec 18 03:18:28 UTC 2022 , Edited by admin on Sun Dec 18 03:18:28 UTC 2022
PRIMARY
WIKIPEDIA
CIPROXIFAN
Created by admin on Sun Dec 18 03:18:28 UTC 2022 , Edited by admin on Sun Dec 18 03:18:28 UTC 2022
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY