SULISATIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H17NO9S2
Molecular Weight	491.491
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC2=C1NC(=O)C2(C3=CC=C(OS(O)(=O)=O)C=C3)C4=CC=C(OS(O)(=O)=O)C=C4

InChI

InChIKey=URNFTLVCQLRCMN-UHFFFAOYSA-N

InChI=1S/C21H17NO9S2/c1-13-3-2-4-18-19(13)22-20(23)21(18,14-5-9-16(10-6-14)30-32(24,25)26)15-7-11-17(12-8-15)31-33(27,28)29/h2-12H,1H3,(H,22,23)(H,24,25,26)(H,27,28,29)

HIDE SMILES / InChI

Molecular Formula	C21H17NO9S2
Molecular Weight	491.491
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1261595 | https://www.ncbi.nlm.nih.gov/pubmed/7138083 | https://www.ncbi.nlm.nih.gov/pubmed/1230028

Sulisatin (also known as DAN-603) is an indolinone derivative patented by Andreu, Dr., S. A. as a laxative. In preclinical models, Sulisatin increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying in rats. Sulisatin is unable to inhibit water absorption in rat colon while small amounts of Sulisatin may inhibit it significantly.

Originator

Approval Year

PubMed

Title	Date	PubMed
Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.	1976 Mar	1261595

Patents

Sample Use Guides

In Vivo Use Guide

rat 1.5, 3 and 6 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:20:51 GMT 2023` Edited by `admin` on `Fri Dec 15 17:20:51 GMT 2023`
Record UNII	5EOG8KQT0Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULISATIN

Official Name

English

SULISATIN [MI]

Common Name

English

sulisatin [INN]

Common Name

English

Sulisatin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29697