SULISATIN SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H15NO9S2.2Na
Molecular Weight	535.455
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].CC1=CC=CC2=C1NC(=O)C2(C3=CC=C(OS([O-])(=O)=O)C=C3)C4=CC=C(OS([O-])(=O)=O)C=C4

InChI

InChIKey=IBJXXCVPQABJRR-UHFFFAOYSA-L

InChI=1S/C21H17NO9S2.2Na/c1-13-3-2-4-18-19(13)22-20(23)21(18,14-5-9-16(10-6-14)30-32(24,25)26)15-7-11-17(12-8-15)31-33(27,28)29;;/h2-12H,1H3,(H,22,23)(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	C21H15NO9S2
Molecular Weight	489.475
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1261595 | https://www.ncbi.nlm.nih.gov/pubmed/7138083 | https://www.ncbi.nlm.nih.gov/pubmed/1230028

Sulisatin (also known as DAN-603) is an indolinone derivative patented by Andreu, Dr., S. A. as a laxative. In preclinical models, Sulisatin increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying in rats. Sulisatin is unable to inhibit water absorption in rat colon while small amounts of Sulisatin may inhibit it significantly.

Originator

Approval Year

PubMed

Title	Date	PubMed
Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.	1976 Mar	1261595

Patents

Sample Use Guides

In Vivo Use Guide

rat 1.5, 3 and 6 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:44:25 GMT 2023` Edited by `admin` on `Fri Dec 15 18:44:25 GMT 2023`
Record UNII	7S636L78GU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SULISATIN SODIUM

Common Name

English

DAN 603

Code

English

Sulisatin sodium [WHO-DD]

Common Name

English

LAXITEX

Brand Name

English

2H-INDOL-2-ONE, 1,3-DIHYDRO-7-METHYL-3,3-BIS(4-(SULFOOXY)PHENYL)-, SODIUM SALT (1:2)

Common Name

English

SODIUM SULISATIN

Common Name

English

DAN-603

Code

English

SULISATIN DISODIUM SALT [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID40203452