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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H12N4O5
Molecular Weight 268.2261
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of INOSINE

SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=NC3=C2N=CNC3=O

InChI

InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N
InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H12N4O5
Molecular Weight 268.2261
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Inosine is a naturally occurring nucleoside which serves as an intermediate in purine metabolism. The metabolism of purines in humans generates a potent antioxidant compound, uric acid, which is known to be a natural scavenger of both oxygen and nitrogen reactive species as well as having chelator properties. Inosine, as a precursor of uric acid, was shown to have neuroprotective effect in vitro and is being tested in phase III of clinical trials for the treatment of Parkinson disease. The treatment with inosine is belived to prevent or slow the disease.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

T1/2

ValueDoseCo-administeredAnalytePopulation
50 min
single, oral
INOSINE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
100%
INOSINE plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
Capsules containing 500 mg of inosine should be taken orally up to two capsules three times per day (i.e., up to 3 g/day) for 24 months.
Route of Administration: Oral
In Vitro Use Guide
Rodent MES 23.5 dopaminergic cell were pretreated with inosine (0.1–100 uM) for 24 hours before addition of the oxidative stress inducer H2O2 (200 uM). Inosine decreased toxicant-induced oxidative stress at 3 hours.
Substance Class Chemical
Record UNII
5A614L51CT
Record Status Validated (UNII)
Record Version