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Details

Stereochemistry ACHIRAL
Molecular Formula C14H16N2
Molecular Weight 212.2902
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NAPACTADINE

SMILES

CN\C(CC1=CC=C2C=CC=CC2=C1)=N/C

InChI

InChIKey=NAHCWQNNENHGNH-UHFFFAOYSA-N
InChI=1S/C14H16N2/c1-15-14(16-2)10-11-7-8-12-5-3-4-6-13(12)9-11/h3-9H,10H2,1-2H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula C14H16N2
Molecular Weight 212.2902
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Napactadine is a bicyclic antidepressant agent. It is a histamine-H1 receptor antagonist. Preliminary results indicated a marked improvement in depressive symptomalology within 7 days of treatment, as measured by the Hamilton depression scale. However, clinical studies were discontinued after chronic administration of napactadine because an elevation in liver enzyme levels was observed in some patients.

Approval Year

PubMed

Substance Class Chemical
Record UNII
571S87U90N
Record Status Validated (UNII)
Record Version