NAPACTADINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N2.ClH
Molecular Weight	248.751
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN\C(CC1=CC2=C(C=CC=C2)C=C1)=N/C

InChI

InChIKey=WEDBCIMSKMMRAG-UHFFFAOYSA-N

InChI=1S/C14H16N2.ClH/c1-15-14(16-2)10-11-7-8-12-5-3-4-6-13(12)9-11;/h3-9H,10H2,1-2H3,(H,15,16);1H

HIDE SMILES / InChI

Molecular Formula	C14H16N2
Molecular Weight	212.2902
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067998 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y

Napactadine is a bicyclic antidepressant agent. It is a histamine-H1 receptor antagonist. Preliminary results indicated a marked improvement in depressive symptomalology within 7 days of treatment, as measured by the Hamilton depression scale. However, clinical studies were discontinued after chronic administration of napactadine because an elevation in liver enzyme levels was observed in some patients.

Approval Year

PubMed

Title	Date	PubMed
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.	1985 Nov	4067998

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:30:38 GMT 2023` Edited by `admin` on `Fri Dec 15 16:30:38 GMT 2023`
Record UNII	9FB1F1BV0M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NAPACTADINE HYDROCHLORIDE

Official Name

English

2-NAPHTHALENEETHANIMIDAMIDE, N,N'-DIMETHYL-, MONOHYDROCHLORIDE

Common Name

English

NAPACTADINE HYDROCHLORIDE [MART.]

Common Name

English

NAPACTADINE HCL

Common Name

English

NAPACTADINE HYDROCHLORIDE [USAN]

Common Name

English

DL-588

Code

English

N,N'-DIMETHYL-2-NAPHTHALENEACETAMIDINE MONOHYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578