AWD-12-281

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H14Cl2FN3O3
Molecular Weight	458.269
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC2=C(C=C1)N(CC3=CC=C(F)C=C3)C=C2C(=O)C(=O)NC4=C(Cl)C=NC=C4Cl

InChI

InChIKey=DPHDSIQHVGSITN-UHFFFAOYSA-N

InChI=1S/C22H14Cl2FN3O3/c23-17-8-26-9-18(24)20(17)27-22(31)21(30)16-11-28(10-12-1-3-13(25)4-2-12)19-6-5-14(29)7-15(16)19/h1-9,11,29H,10H2,(H,26,27,31)

HIDE SMILES / InChI

Molecular Formula	C22H14Cl2FN3O3
Molecular Weight	458.269
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice.	2009-05-20	19457265
Treating COPD with PDE 4 inhibitors.	2007	18268925
Biological targets for therapeutic interventions in COPD: clinical potential.	2006	18046869
Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations.	2004-02	14610230
In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration.	2003-10	12944497
AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis.	2003-08	12956900
Effects of the phosphodiesterase 4 inhibitors SB 207499 and AWD 12-281 on the inflammatory reaction in a model of allergic dermatitis.	2002-06-20	12098602

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:47:24 GMT 2025` Edited by `admin` on `Mon Mar 31 21:47:24 GMT 2025`
Record UNII	550671J24D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AWD-12-281

Code

English

GSK-842470

Preferred Name

English

1H-INDOLE-3-ACETAMIDE, N-(3,5-DICHLORO-4-PYRIDINYL)-1-((4-FLUOROPHENYL)METHYL)-5-HYDROXY-.ALPHA.-OXO-

Systematic Name

English

GW-842470

Code

English

GW842470X

Code

English

Code System Code Type Description

FDA UNII

550671J24D