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Details

Stereochemistry ACHIRAL
Molecular Formula C15H9ClO2
Molecular Weight 256.684
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLORINDIONE

SMILES

ClC1=CC=C(C=C1)C2C(=O)C3=C(C=CC=C3)C2=O

InChI

InChIKey=NJDUWAXIURWWLN-UHFFFAOYSA-N
InChI=1S/C15H9ClO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

HIDE SMILES / InChI

Molecular Formula C15H9ClO2
Molecular Weight 256.684
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Clorindione belongs to a class of drugs which are known to be vitamin K antagonists, and is a derivative of phenindione. It has been demonstrated as effective in reducing prothrombin levels in humans and also to reduce serum cholesterol and triglycerides in mice.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
32 patients were treated in hospital and administered oral tablets of clorindione; 12 mg on the first day, 8 mg on the second day, and 4 mg on the third day. Because of the delayed action of clorindione, Heparin 10,000 iu was given by intramuscular injection on admission and then 5,000 iu every 6 hours for 3 days at 24-hour intervals. Clorindione effectively reduced the prothrombin levels in the patient population back to the desired therapeutic range by the fourth day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
541C7WS64R
Record Status Validated (UNII)
Record Version