CLORINDIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H9ClO2
Molecular Weight	256.684
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2C(=O)C3=C(C=CC=C3)C2=O

InChI

InChIKey=NJDUWAXIURWWLN-UHFFFAOYSA-N

InChI=1S/C15H9ClO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

HIDE SMILES / InChI

Molecular Formula	C15H9ClO2
Molecular Weight	256.684
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.rxwiki.com/clorindione | https://www.ncbi.nlm.nih.gov/pubmed/4067989 | https://www.ncbi.nlm.nih.gov/pubmed/21313725

Clorindione belongs to a class of drugs which are known to be vitamin K antagonists, and is a derivative of phenindione. It has been demonstrated as effective in reducing prothrombin levels in humans and also to reduce serum cholesterol and triglycerides in mice.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
triglyceride biosynthetic process 1 Target ID: GO:0019432 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067989	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypercholesterolemia 47 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4067989	Primary		Not Provided 504	Unknown Approved Use Unknown
Anticoagulant 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21313725	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[ON THE VALUE OF CHLORPHENYLINDANDIONE IN THE THERAPY OF THROMBOEMBOLISM].	1964 Feb 29	14153214
A Trial of Clorindione-A Long Acting Oral Anticoagulant.	1965 Dec	21313725
Hypolipidemic activity of indan-1,3-dione derivatives in rodents.	1985 Nov	4067989

Patents

Sample Use Guides

In Vivo Use Guide

32 patients were treated in hospital and administered oral tablets of clorindione; 12 mg on the first day, 8 mg on the second day, and 4 mg on the third day. Because of the delayed action of clorindione, Heparin 10,000 iu was given by intramuscular injection on admission and then 5,000 iu every 6 hours for 3 days at 24-hour intervals. Clorindione effectively reduced the prothrombin levels in the patient population back to the desired therapeutic range by the fourth day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:42:00 GMT 2023` Edited by `admin` on `Fri Dec 15 17:42:00 GMT 2023`
Record UNII	541C7WS64R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLORINDIONE

Official Name

English

CLORINDIONE [MI]

Common Name

English

Clorindione [WHO-DD]

Common Name

English

clorindione [INN]

Common Name

English

NSC-758878

Code

English

G-25766

Code

English

2-(P-CHLOROPHENYL)-1,3-INDANDION

Common Name

English

Classification Tree Code System Code

WHO-ATC

B01AA09