ACAVAMERAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 08:16:22 GMT 2025` Edited by `admin` on `Wed Apr 02 08:16:22 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	4Y426OW1GF
Record Status	`FAILED`
Record Version

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Name

Type

Language

MESSENGER RNA (MRNA), 5' CAPPED, ENCODING TUMOUR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4 (TNFSF4, OX40 LIGAND, OX40L, GLYCOPROTEIN GP34), FLANKED BY 5' AND 3' UNTRANSLATED REGIONS AND A 3' POLYA TAIL; CONTAINS N1-METHYLPSEUDOURIDINE INSTEAD OF URIDIN

Preferred Name

English

ACAVAMERAN

Official Name

English

RNA (ALL URIDINE->N1-METHYLPSEUDOURIDINE-SUBSTITUTED HUMAN GENE TNFSF4 CD252 ANTIGEN-SPECIFYING MESSENGER PLUS FLANKS)

Common Name

English

acavameran [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C179068

Created by admin on Wed Apr 02 08:16:22 GMT 2025 , Edited by admin on Wed Apr 02 08:16:22 GMT 2025

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SMS_ID

300000038029

Created by admin on Wed Apr 02 08:16:22 GMT 2025 , Edited by admin on Wed Apr 02 08:16:22 GMT 2025

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FDA UNII

4Y426OW1GF

Created by admin on Wed Apr 02 08:16:22 GMT 2025 , Edited by admin on Wed Apr 02 08:16:22 GMT 2025

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INN

11264

Created by admin on Wed Apr 02 08:16:22 GMT 2025 , Edited by admin on Wed Apr 02 08:16:22 GMT 2025

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INN

CAS

2159155-74-3

Created by admin on Wed Apr 02 08:16:22 GMT 2025 , Edited by admin on Wed Apr 02 08:16:22 GMT 2025

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Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_2	1 / 845
D-Ribose (RNA)	1_3-1_846	844 / 845

Linkage	Site Range	Site Count
Phosphate	1_2-1_846	845 / 844

Related Record Type Details


					SD6YM06CAN

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					4Y426OW1GF

ACTIVE MOIETY

Comments:

OX40 ligand stimulants

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		6-METHYLPSEUDOURIDINE	2W14ED8VLI