ACAVAMERAN

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 16:41:05 GMT 2023` Edited by `admin` on `Sat Dec 16 16:41:05 GMT 2023`
Nucleic Acid Type	MRNA
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	4Y426OW1GF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACAVAMERAN

Official Name

English

MESSENGER RNA (MRNA), 5' CAPPED, ENCODING TUMOUR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4 (TNFSF4, OX40 LIGAND, OX40L, GLYCOPROTEIN GP34), FLANKED BY 5' AND 3' UNTRANSLATED REGIONS AND A 3' POLYA TAIL; CONTAINS N1-METHYLPSEUDOURIDINE INSTEAD OF URIDIN

Common Name

English

RNA (ALL URIDINE->N1-METHYLPSEUDOURIDINE-SUBSTITUTED HUMAN GENE TNFSF4 CD252 ANTIGEN-SPECIFYING MESSENGER PLUS FLANKS)

Common Name

English

acavameran [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C179068

Created by admin on Sat Dec 16 16:41:05 GMT 2023 , Edited by admin on Sat Dec 16 16:41:05 GMT 2023

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FDA UNII

4Y426OW1GF

Created by admin on Sat Dec 16 16:41:05 GMT 2023 , Edited by admin on Sat Dec 16 16:41:05 GMT 2023

PRIMARY

INN

11264

Created by admin on Sat Dec 16 16:41:05 GMT 2023 , Edited by admin on Sat Dec 16 16:41:05 GMT 2023

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INN

CAS

2159155-74-3

Created by admin on Sat Dec 16 16:41:05 GMT 2023 , Edited by admin on Sat Dec 16 16:41:05 GMT 2023

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Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_2	1 / 845
D-Ribose (RNA)	1_3-1_846	844 / 845

Linkage	Site Range	Site Count
Phosphate	1_2-1_846	845 / 844

Related Record Type Details


					SD6YM06CAN

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					4Y426OW1GF

ACAVAMERAN

ACTIVE MOIETY

Comments:

OX40 ligand stimulants

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		6-METHYLPSEUDOURIDINE	2W14ED8VLI