ONDELOPRAN

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H24FN3O3
Molecular Weight	373.4213
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CN=C(OC2=CC=C(CNCCC3CCOCC3)C=C2F)C=C1

InChI

InChIKey=QWNDOCKIKKQJNN-UHFFFAOYSA-N

InChI=1S/C20H24FN3O3/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25)

HIDE SMILES / InChI

Molecular Formula	C20H24FN3O3
Molecular Weight	373.4213
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT03663374 | https://www.ncbi.nlm.nih.gov/pubmed/24010675

Ondelopran (also known as LY2196044) was developed as orally available opioid receptor antagonist for the treatment of alcoholism. This drug completed clinical trials phase III where was assess its efficacy and safety in the treatment of alcohol dependence in adult outpatients.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Opioid receptors; mu/kappa/delta 33 Target ID: CHEMBL2095181 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24010675 \| https://adisinsight.springer.com/drugs/800029390	Antagonist 2849

Sample Use Guides

In Vivo Use Guide

One tablet once daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:27:35 GMT 2025` Edited by `admin` on `Mon Mar 31 18:27:35 GMT 2025`
Record UNII	4VZT670SD9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ONDELOPRAN

Official Name

English

ondelopran [INN]

Preferred Name

English

Ondelopran [WHO-DD]

Common Name

English

LY-2196044

Code

English

ONDELOPRAN [USAN]

Common Name

English

LY2196044

Code

English

6-(2-FLUORO-4-(((2-(OXAN-4-YL)ETHYL)AMINO)METHYL)PHENOXY)PYRIDINE-3-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

USAN

WW-129