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Details

Stereochemistry ACHIRAL
Molecular Formula C20H24FN3O3
Molecular Weight 373.4213
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ONDELOPRAN

SMILES

NC(=O)C1=CN=C(OC2=C(F)C=C(CNCCC3CCOCC3)C=C2)C=C1

InChI

InChIKey=QWNDOCKIKKQJNN-UHFFFAOYSA-N
InChI=1S/C20H24FN3O3/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25)

HIDE SMILES / InChI
Molecular Formula C20H24FN3O3
Molecular Weight 373.4213
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ondelopran (also known as LY2196044) was developed as orally available opioid receptor antagonist for the treatment of alcoholism. This drug completed clinical trials phase III where was assess its efficacy and safety in the treatment of alcohol dependence in adult outpatients.

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Opioid receptors; mu/kappa/delta
33
Antagonist
2,778

Sample Use Guides

In Vivo Use Guide
One tablet once daily
Route of Administration: Oral
Substance Class Chemical
Record UNII
4VZT670SD9
Record Status Validated (UNII)
Record Version
NIH
NCATS
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