ONDELOPRAN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H24FN3O3.ClH
Molecular Weight	409.882
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC(=O)C1=CN=C(OC2=C(F)C=C(CNCCC3CCOCC3)C=C2)C=C1

InChI

InChIKey=UQHILNMISZVWIW-UHFFFAOYSA-N

InChI=1S/C20H24FN3O3.ClH/c21-17-11-15(12-23-8-5-14-6-9-26-10-7-14)1-3-18(17)27-19-4-2-16(13-24-19)20(22)25;/h1-4,11,13-14,23H,5-10,12H2,(H2,22,25);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H24FN3O3
Molecular Weight	373.4213
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT03663374 | https://www.ncbi.nlm.nih.gov/pubmed/24010675

Ondelopran (also known as LY2196044) was developed as orally available opioid receptor antagonist for the treatment of alcoholism. This drug completed clinical trials phase III where was assess its efficacy and safety in the treatment of alcohol dependence in adult outpatients.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Opioid receptors; mu/kappa/delta 33 Target ID: CHEMBL2095181 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24010675 \| https://adisinsight.springer.com/drugs/800029390	Antagonist 2778

Sample Use Guides

In Vivo Use Guide

One tablet once daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:39:56 GMT 2023` Edited by `admin` on `Fri Dec 15 15:39:56 GMT 2023`
Record UNII	Z5X95DWF8B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ONDELOPRAN HYDROCHLORIDE

Official Name

English

ONDELOPRAN HCL

Common Name

English

LY-2196044 HYDROCHLORIDE

Code

English

LY-2196044 HCL

Code

English

LY2196044 HCL

Code

English

LY2196044 HYDROCHLORIDE

Code

English

6-(2-FLUORO-4-(((2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL)AMINO)METHYL)PHENOXY)PYRIDINE-3- CARBOXAMIDE MONOHYDROCHLORIDE

Systematic Name

English

3-PYRIDINECARBOXAMIDE, 6-(2-FLUORO-4-(((2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL)AMINO)METHYL)PHENOXY)-, HYDROCHLORIDE (1:1)

Systematic Name

English

ONDELOPRAN HYDROCHLORIDE [USAN]

Common Name

English

Ondelopran hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

USAN

WW-130