P-ANISIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H8O3
Molecular Weight	152.1473
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(O)=O

InChI

InChIKey=ZEYHEAKUIGZSGI-UHFFFAOYSA-N

InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C8H8O3
Molecular Weight	152.1473
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://cosmetics.specialchem.com/inci/sodium-anisate | https://nairian.am/en/ingredients/sodium-anisate | https://www.ulprospector.com/en/la/PersonalCare/Detail/2448/371651/dermosoft-anisate

SODIUM ANISATE is derived from fennel, this is the sodium salt of p-anisic acid. It is classified as antimicrobial and flavouring. It acts as an anti-fungal agent, and when paired with sodium levulinate the two ingredients make for a comprehensive preservative for cosmetics. This ingredient is approved for use in organic cosmetics. Sodium anisate (dermosoft® anisate) is an easy to use water soluble salt of an organic acid with an excellent fungicidal activity. It can be added to the cold or hot water phase at any step of the process. The combination with antimicrobial surface active substances or organic acids is recommended to improve the performance of the product even at higher pH.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbonic anhydrase 2 5 Target ID: CHEMBL1697676 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21402476	Inhibitor 8297		9.9 nM [Ki]
Phospholipase A2 9 Target ID: P00593 Gene ID: 104974671\|\|\|282457 Gene Symbol: PLA2G1B Target Organism: Bos taurus (Bovine) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16552140 \| https://www.ncbi.nlm.nih.gov/pubmed/14529623	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Fungal infection 21 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21402476	Primary		Basic research	Unknown Approved Use Unknown
Acne 98 Sources: https://www.drugs.com/otc/633317/thera-wise-natural-acne.html	Inactive ingredient		Approved 8429	Thera Wise Natural Acne Approved Use Helps treat acne pimples and allows skin to heal

PubMed

Title	Date	PubMed
Biodegradation of hydroxylated and methoxylated benzoic, phenylacetic and phenylpropenoic acids present in olive mill wastewaters by two bacterial strains.	2001 Jan-Feb	11281329
Diterpenes and other constituents from Croton draco (Euphorbiaceae).	2001 Mar	11795154
Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans.	2001 May	11409548
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.	2001 May 18	11412837
The trans-anethole degradation pathway in an Arthrobacter sp.	2002 Apr 5	11805095
The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.	2002 Jan 31	11834304
Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells.	2002 Oct	12376665
Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter.	2003 Aug	14531622
Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr.	2004 Apr	14984087
SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes.	2006 May	16464627
Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment.	2007 Nov	17976265
Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification.	2008 Aug	18542947
Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats.	2008 Jan	19902032
Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase.	2008 Jul	18704333
Antioxidant constituents of Nymphaea caerulea flowers.	2008 Jul	18534639
Chemical constituents from leaves of Palicourea coriacea (Rubiaceae).	2008 Jul	18404310
Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B. Jararacussu.	2008 May	19325781
[Quantitative monitoring the concentration changes of organic acids in fermentation process of Clostridium acetobutylicum using capillary ion electrophoresis].	2008 Nov	19253539
Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris.	2008 Nov 14	18762195
Home-prepared anatase, rutile, and brookite TiO(2) for selective photocatalytic oxidation of 4-methoxybenzyl alcohol in water: reactivity and ATR-FTIR study.	2009 May	19424540
Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells.	2009 Sep 14	19446539
Variations in IC(50) values with purity of mushroom tyrosinase.	2009 Sep 2	19865520
Bis(4-meth-oxy-benzoato)-κO,O';κO-bis-(nicotinamide-κN)zinc(II).	2010 Aug 21	21588535
Diaqua-bis-(4-meth-oxy-benzoato-κO)bis-(nicotinamide-κN)cobalt(II) dihydrate.	2010 Jul 10	21588149
N'-[Bis(benzyl-sulfan-yl)methyl-idene]-4-meth-oxy-benzohydrazide.	2010 Jul 3	21588233
Bis[μ-2,2'-dimethyl-1,1'-(3-oxapentane-1,5-di-yl)di-1H-benzimidazole-κN:N]bis-[bis-(4-meth-oxy-benzoato)-κO;κO,O'-cobalt(II)].	2010 Nov 13	21589242
2,5-Bis(4-meth-oxy-phen-yl)-1,3,4-oxadiazole.	2010 Nov 6	21589381

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

4-methoxy-benzoic acid inhibited β-carbonic anhydrase (EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) with IC50 value of 9.9 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:35:01 GMT 2023` Edited by `admin` on `Fri Dec 15 17:35:01 GMT 2023`
Record UNII	4SB6Y7DMM3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

P-ANISIC ACID

Official Name

English

4-ANISIC ACID

Systematic Name

English

DRACONIC ACID

Common Name

English

P-ANISIC ACID [INCI]

Common Name

English

NSC-32742

Code

English

P-ANISIC ACID [MI]

Common Name

English

4-METHOXYBENZOIC ACID [FHFI]

Code

English

4-METHOXYBENZOIC ACID

Systematic Name

English

FEMA NO. 3945

Code

English

Classification Tree Code System Code

JECFA EVALUATION

4-METHOXYBENZOIC ACID