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Details

Stereochemistry ACHIRAL
Molecular Formula C8H8O3
Molecular Weight 152.1473
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of P-ANISIC ACID

SMILES

COC1=CC=C(C=C1)C(O)=O

InChI

InChIKey=ZEYHEAKUIGZSGI-UHFFFAOYSA-N
InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C8H8O3
Molecular Weight 152.1473
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM ANISATE is derived from fennel, this is the sodium salt of p-anisic acid. It is classified as antimicrobial and flavouring. It acts as an anti-fungal agent, and when paired with sodium levulinate the two ingredients make for a comprehensive preservative for cosmetics. This ingredient is approved for use in organic cosmetics. Sodium anisate (dermosoft® anisate) is an easy to use water soluble salt of an organic acid with an excellent fungicidal activity. It can be added to the cold or hot water phase at any step of the process. The combination with antimicrobial surface active substances or organic acids is recommended to improve the performance of the product even at higher pH.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
9.9 nM [Ki]
Target ID: P00593
Gene ID: 104974671|||282457
Gene Symbol: PLA2G1B
Target Organism: Bos taurus (Bovine)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Inactive ingredient
Thera Wise Natural Acne

Approved Use

Helps treat acne pimples and allows skin to heal
PubMed

PubMed

TitleDatePubMed
[Theophylline-sodium anisate].
1955 Aug 13
New 4-methoxybenzoyl derivatives from the ascidian Polycarpa aurata.
2001 Dec
Diterpenes and other constituents from Croton draco (Euphorbiaceae).
2001 Mar
Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans.
2001 May
The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.
2002 Jan 31
Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.
2003 Apr
Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.
2003 Oct 9
A universal HPLC method for the determination of phenolic acids in compound herbal medicines.
2005 Aug 24
Identification of syn- and anti-anethole-2,3-epoxides in the metabolism of trans-anethole by the newly isolated bacterium Pseudomonas putida JYR-1.
2005 Jul 27
Synthesis of 5,6-dimethyl-9-methoxy-1-phenyl-6H-pyrido[4,3-b]carbazole derivatives and their cytotoxic activity.
2005 Nov
[Studies on luminescence properties of seven ternary complexes of terbium with 1,10-phenanthroline and benzoic acid and its derivatives].
2006 Apr
Crystal structures of the complexes of a group IIA phospholipase A2 with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding.
2006 Jul 1
[Studies on chemical constituents of cytotoxic fraction from leaves of Elaeagnus pungens].
2006 Mar
Structural biology of recombinant bovine pancreatic phospholipase A2 and its inhibitor complexes.
2007
First general, direct, and regioselective synthesis of substituted methoxybenzoic acids by ortho metalation.
2007 Apr 27
Inhibitory effect of Hemidesmus indicus and its active principle 2-hydroxy 4-methoxy benzoic acid on ethanol-induced liver injury.
2007 Oct
Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase.
2008 Jul
Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B. Jararacussu.
2008 May
[Quantitative monitoring the concentration changes of organic acids in fermentation process of Clostridium acetobutylicum using capillary ion electrophoresis].
2008 Nov
Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris.
2008 Nov 14
An updated review of tyrosinase inhibitors.
2009 May 26
Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells.
2009 Sep 14
Variations in IC(50) values with purity of mushroom tyrosinase.
2009 Sep 2
N'-[Bis(benzyl-sulfan-yl)methyl-idene]-4-meth-oxy-benzohydrazide.
2010 Jul 3
Bis[μ-2,2'-dimethyl-1,1'-(oxydiethyl-ene)bis-(1H-benzimidazole)-κN:N]bis-[bis-(4-methoxy-benzoato-κO,O')cadmium(II)].
2010 Mar 20
2,5-Bis(4-meth-oxy-phen-yl)-1,3,4-oxadiazole.
2010 Nov 6
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
4-methoxy-benzoic acid inhibited β-carbonic anhydrase (EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) with IC50 value of 9.9 nM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:35:01 UTC 2023
Edited
by admin
on Fri Dec 15 17:35:01 UTC 2023
Record UNII
4SB6Y7DMM3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
P-ANISIC ACID
INCI   MI  
INCI  
Official Name English
4-ANISIC ACID
Systematic Name English
DRACONIC ACID
Common Name English
P-ANISIC ACID [INCI]
Common Name English
NSC-32742
Code English
P-ANISIC ACID [MI]
Common Name English
4-METHOXYBENZOIC ACID [FHFI]
Code English
4-METHOXYBENZOIC ACID
FHFI  
Systematic Name English
FEMA NO. 3945
Code English
Classification Tree Code System Code
JECFA EVALUATION 4-METHOXYBENZOIC ACID
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
Code System Code Type Description
DAILYMED
4SB6Y7DMM3
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
NSC
32742
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
FDA UNII
4SB6Y7DMM3
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
CAS
100-09-4
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PRIMARY
RXCUI
1426595
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PRIMARY RxNorm
SMS_ID
300000044637
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PRIMARY
JECFA MONOGRAPH
719
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PRIMARY
PUBCHEM
7478
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
EPA CompTox
DTXSID4059205
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
MERCK INDEX
m1929
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
202-818-5
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PRIMARY
DRUG BANK
DB02795
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
CHEBI
40813
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
WIKIPEDIA
P-ANISIC ACID
Created by admin on Fri Dec 15 17:35:01 UTC 2023 , Edited by admin on Fri Dec 15 17:35:01 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
4-Methoxybenzoic acid content for water extract of plant leaf was 33.80+/-0.65 and plant callus was 44 +/- 0.31 expressed as mg/100 g of dry base of extract. For the analysis of phenolic acids, a Nova pack C18 UG120 equipped with a Guard column, a JASCO HPLC system consisting of a column oven, a UV-Vis diode array detector set at 280 nm, a Liquid chromatography pump and a ChromNAV software program were used.