Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.1473 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)C(O)=O
InChI
InChIKey=ZEYHEAKUIGZSGI-UHFFFAOYSA-N
InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.1473 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
SODIUM ANISATE is derived from fennel, this is the sodium salt of p-anisic acid. It is classified as antimicrobial and flavouring. It acts as an anti-fungal agent, and when paired with sodium levulinate the two ingredients make for a comprehensive preservative for cosmetics. This ingredient is approved for use in organic cosmetics. Sodium anisate (dermosoft® anisate) is an easy to use water soluble salt of an organic acid with an excellent fungicidal activity. It can be added to the cold or hot water phase at any step of the process. The combination with antimicrobial surface active substances or organic acids is recommended to improve the performance of the product even at higher pH.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1697676 |
9.9 nM [Ki] | ||
Target ID: P00593 Gene ID: 104974671|||282457 Gene Symbol: PLA2G1B Target Organism: Bos taurus (Bovine) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Inactive ingredient | Thera Wise Natural Acne Approved UseHelps treat acne pimples and allows skin to heal |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Theophylline-sodium anisate]. | 1955 Aug 13 |
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| Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter. | 2003 Aug |
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| Tyrosinase inhibition kinetics of anisic acid. | 2003 Sep-Oct |
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| Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr. | 2004 Apr |
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| A universal HPLC method for the determination of phenolic acids in compound herbal medicines. | 2005 Aug 24 |
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| Identification of syn- and anti-anethole-2,3-epoxides in the metabolism of trans-anethole by the newly isolated bacterium Pseudomonas putida JYR-1. | 2005 Jul 27 |
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| Kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD). | 2005 Jul-Aug |
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| Synthesis of 5,6-dimethyl-9-methoxy-1-phenyl-6H-pyrido[4,3-b]carbazole derivatives and their cytotoxic activity. | 2005 Nov |
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| Quick determination of malodor-causing fatty acids in manure by capillary electrophoresis. | 2005 Sep |
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| [Studies on luminescence properties of seven ternary complexes of terbium with 1,10-phenanthroline and benzoic acid and its derivatives]. | 2006 Apr |
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| Third calcium ion found in an inhibitor-bound phospholipase A2. | 2006 Apr |
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| Crystal structures of the complexes of a group IIA phospholipase A2 with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding. | 2006 Jul 1 |
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| [Studies on chemical constituents of cytotoxic fraction from leaves of Elaeagnus pungens]. | 2006 Mar |
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| Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris. | 2006 Mar 31 |
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| SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes. | 2006 May |
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| Structural biology of recombinant bovine pancreatic phospholipase A2 and its inhibitor complexes. | 2007 |
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| First general, direct, and regioselective synthesis of substituted methoxybenzoic acids by ortho metalation. | 2007 Apr 27 |
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| Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment. | 2007 Nov |
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| Inhibitory effect of Hemidesmus indicus and its active principle 2-hydroxy 4-methoxy benzoic acid on ethanol-induced liver injury. | 2007 Oct |
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| Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. | 2008 Aug |
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| Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats. | 2008 Jan |
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| Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase. | 2008 Jul |
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| Antioxidant constituents of Nymphaea caerulea flowers. | 2008 Jul |
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| Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). | 2008 Jul |
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| Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B. Jararacussu. | 2008 May |
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| [Quantitative monitoring the concentration changes of organic acids in fermentation process of Clostridium acetobutylicum using capillary ion electrophoresis]. | 2008 Nov |
|
| Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. | 2008 Nov 14 |
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| A novel norditerpenoid alkaloid from Aconitum macrorhynchum. | 2009 Aug |
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| Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris. | 2009 Dec |
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| Antioxidant and radical scavenging properties of Malva sylvestris. | 2009 Jul |
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| Home-prepared anatase, rutile, and brookite TiO(2) for selective photocatalytic oxidation of 4-methoxybenzyl alcohol in water: reactivity and ATR-FTIR study. | 2009 May |
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| An updated review of tyrosinase inhibitors. | 2009 May 26 |
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| Aryl-alcohol oxidase involved in lignin degradation: a mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates. | 2009 Sep 11 |
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| Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells. | 2009 Sep 14 |
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| Variations in IC(50) values with purity of mushroom tyrosinase. | 2009 Sep 2 |
|
| Tetra-kis(μ-4-methoxy-benzoato)bis-[(4-methoxy-benzoato)(1,10-phenan-throline)terbium(III)]. | 2009 Sep 26 |
|
| Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination. | 2009 Sep 4 |
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| Bis(4-meth-oxy-benzoato)-κO,O';κO-bis-(nicotinamide-κN)zinc(II). | 2010 Aug 21 |
|
| 2-hydroxy 4-methoxy benzoic acid isolated from roots of Hemidesmus indicus ameliorates liver, kidney and pancreas injury due to streptozotocin-induced diabetes in rats. | 2010 Feb |
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| Diaqua-bis-(4-meth-oxy-benzoato-κO)bis-(nicotinamide-κN)cobalt(II) dihydrate. | 2010 Jul 10 |
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| N'-[Bis(benzyl-sulfan-yl)methyl-idene]-4-meth-oxy-benzohydrazide. | 2010 Jul 3 |
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| Diaqua-bis-(4-meth-oxy-benzoato-κO)bis-(nicotinamide-κN)nickel(II) dihydrate. | 2010 Jul 7 |
|
| Di-μ-nicotinamide-κO:N;κN:O-bis-[aqua-bis-(4-meth-oxy-benzoato-κO)copper(II)]. | 2010 Jun 16 |
|
| Diaqua-(isonicotinamide-κN)(4-meth-oxy-benzoato-κO,O')(4-meth-oxy-benzoato-κO)cobalt(II). | 2010 Jun 16 |
|
| Protein recognition in ferredoxin-P450 electron transfer in the class I CYP199A2 system from Rhodopseudomonas palustris. | 2010 Mar |
|
| Bis[μ-2,2'-dimethyl-1,1'-(oxydiethyl-ene)bis-(1H-benzimidazole)-κN:N]bis-[bis-(4-methoxy-benzoato-κO,O')cadmium(II)]. | 2010 Mar 20 |
|
| New alternatives to cosmetics preservation. | 2010 Mar-Apr |
|
| Bis[μ-2,2'-dimethyl-1,1'-(3-oxapentane-1,5-di-yl)di-1H-benzimidazole-κN:N]bis-[bis-(4-meth-oxy-benzoato)-κO;κO,O'-cobalt(II)]. | 2010 Nov 13 |
|
| 2,5-Bis(4-meth-oxy-phen-yl)-1,3,4-oxadiazole. | 2010 Nov 6 |
|
| Relationship between chemical structure and biological activity of alkali metal o-, m- and p-anisates. FT-IR and microbiological studies. | 2011 Nov |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Thu Jul 06 00:53:56 UTC 2023
by
admin
on
Thu Jul 06 00:53:56 UTC 2023
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| Record UNII |
4SB6Y7DMM3
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| Record Status |
Validated (UNII)
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| Record Version |
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JECFA EVALUATION |
4-METHOXYBENZOIC ACID
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4SB6Y7DMM3
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32742
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4SB6Y7DMM3
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1426595
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300000044637
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7478
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202-818-5
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DB02795
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40813
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P-ANISIC ACID
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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SALT/SOLVATE -> PARENT | |||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
4-Methoxybenzoic acid content for water extract of plant leaf was 33.80+/-0.65 and plant callus was 44 +/- 0.31 expressed as mg/100 g of dry base of extract.
For the analysis of phenolic acids, a Nova pack C18 UG120 equipped with a Guard column, a JASCO HPLC system consisting of a column oven, a UV-Vis diode array detector set at 280 nm, a Liquid chromatography pump and a ChromNAV software program were used.
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