SODIUM ANISATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H7O3.Na
Molecular Weight	174.1291
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COC1=CC=C(C=C1)C([O-])=O

InChI

InChIKey=AETSDHMVQHOYPB-UHFFFAOYSA-M

InChI=1S/C8H8O3.Na/c1-11-7-4-2-6(3-5-7)8(9)10;/h2-5H,1H3,(H,9,10);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C8H7O3
Molecular Weight	151.1394
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://cosmetics.specialchem.com/inci/sodium-anisate | https://nairian.am/en/ingredients/sodium-anisate | https://www.ulprospector.com/en/la/PersonalCare/Detail/2448/371651/dermosoft-anisate

SODIUM ANISATE is derived from fennel, this is the sodium salt of p-anisic acid. It is classified as antimicrobial and flavouring. It acts as an anti-fungal agent, and when paired with sodium levulinate the two ingredients make for a comprehensive preservative for cosmetics. This ingredient is approved for use in organic cosmetics. Sodium anisate (dermosoft® anisate) is an easy to use water soluble salt of an organic acid with an excellent fungicidal activity. It can be added to the cold or hot water phase at any step of the process. The combination with antimicrobial surface active substances or organic acids is recommended to improve the performance of the product even at higher pH.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbonic anhydrase 2 5 Target ID: CHEMBL1697676 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21402476	Inhibitor 8146		9.9 nM [Ki]
Phospholipase A2 5 Target ID: P00593 Gene ID: 104974671\|\|\|282457 Gene Symbol: PLA2G1B Target Organism: Bos taurus (Bovine) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16552140 \| https://www.ncbi.nlm.nih.gov/pubmed/14529623	Binding Agent 1037

Conditions

Condition	Modality	Targets	Highest Phase	Product
Fungal infection 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21402476	Primary		Basic research	Unknown Approved Use Unknown
Acne 98 Sources: https://www.drugs.com/otc/633317/thera-wise-natural-acne.html	Inactive ingredient		Approved 8307	Thera Wise Natural Acne Approved Use Helps treat acne pimples and allows skin to heal

PubMed

Title	Date	PubMed
Biodegradation of hydroxylated and methoxylated benzoic, phenylacetic and phenylpropenoic acids present in olive mill wastewaters by two bacterial strains.	2001 Jan-Feb	11281329
Diterpenes and other constituents from Croton draco (Euphorbiaceae).	2001 Mar	11795154
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.	2001 May 18	11412837
Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP.	2001 Oct 19	11597608
The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway.	2002 Jan 31	11834304
Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.	2003 Apr	12697467
Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter.	2003 Aug	14531622
Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.	2003 Oct 9	14511910
Tyrosinase inhibition kinetics of anisic acid.	2003 Sep-Oct	14577637
Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr.	2004 Apr	14984087
Synthesis of 5,6-dimethyl-9-methoxy-1-phenyl-6H-pyrido[4,3-b]carbazole derivatives and their cytotoxic activity.	2005 Nov	16281305
Crystal structures of the complexes of a group IIA phospholipase A2 with two natural anti-inflammatory agents, anisic acid, and atropine reveal a similar mode of binding.	2006 Jul 1	16596639
[Studies on chemical constituents of cytotoxic fraction from leaves of Elaeagnus pungens].	2006 Mar	16722375
SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes.	2006 May	16464627
Antioxidant constituents of Nymphaea caerulea flowers.	2008 Jul	18534639
Chemical constituents from leaves of Palicourea coriacea (Rubiaceae).	2008 Jul	18404310
[Quantitative monitoring the concentration changes of organic acids in fermentation process of Clostridium acetobutylicum using capillary ion electrophoresis].	2008 Nov	19253539
A novel norditerpenoid alkaloid from Aconitum macrorhynchum.	2009 Aug	20183315
Variations in IC(50) values with purity of mushroom tyrosinase.	2009 Sep 2	19865520
Tetra-kis(μ-4-methoxy-benzoato)bis-[(4-methoxy-benzoato)(1,10-phenan-throline)terbium(III)].	2009 Sep 26	21577758
Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination.	2009 Sep 4	19732425
Bis(4-meth-oxy-benzoato)-κO,O';κO-bis-(nicotinamide-κN)zinc(II).	2010 Aug 21	21588535
Di-μ-nicotinamide-κO:N;κN:O-bis-[aqua-bis-(4-meth-oxy-benzoato-κO)copper(II)].	2010 Jun 16	21587726
Protein recognition in ferredoxin-P450 electron transfer in the class I CYP199A2 system from Rhodopseudomonas palustris.	2010 Mar	19904564
Bis[μ-2,2'-dimethyl-1,1'-(oxydiethyl-ene)bis-(1H-benzimidazole)-κN:N]bis-[bis-(4-methoxy-benzoato-κO,O')cadmium(II)].	2010 Mar 20	21580526
New alternatives to cosmetics preservation.	2010 Mar-Apr	20447363
2,5-Bis(4-meth-oxy-phen-yl)-1,3,4-oxadiazole.	2010 Nov 6	21589381
Relationship between chemical structure and biological activity of alkali metal o-, m- and p-anisates. FT-IR and microbiological studies.	2011 Nov	21852187

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

4-methoxy-benzoic acid inhibited β-carbonic anhydrase (EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) with IC50 value of 9.9 nM.

Substance Class	Chemical Created by `admin` on `Sat Dec 17 19:17:19 UTC 2022` Edited by `admin` on `Sat Dec 17 19:17:19 UTC 2022`
Record UNII	F9WFJ28MV9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SODIUM ANISATE

Official Name

English

BENZOIC ACID, 4-METHOXY-, SODIUM SALT (1:1)

Common Name

English

SODIUM P-ANISATE

Common Name

English

SODIUM P-METHOXYBENZOATE

Common Name

English

SODIUM ANISATE [INCI]

Common Name

English

Code System Code Type Description

DAILYMED

F9WFJ28MV9