ST-1936

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H17ClN2
Molecular Weight	236.74
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC1=C(C)NC2=CC=C(Cl)C=C12

InChI

InChIKey=KSYMELKKLOFABL-UHFFFAOYSA-N

InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C13H17ClN2
Molecular Weight	236.74
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21549693 | https://www.ncbi.nlm.nih.gov/pubmed/21645553

ST1936 is a potent serotonin 6 (5-HT6) receptor agonist with activity in animal pharmacological models for central nervous system disorders: effect of ST 1936 was investigated on depression-like experimental models. In addition, ST 1936 displays moderate affinity for human α2 adrenergic receptors, shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 6 (5-HT6) receptor 45 Target ID: CHEMBL3371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21549693	Agonist 2678		28.8 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21645553	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.	2005 Oct 1	16055331

Patents

Sample Use Guides

In Vivo Use Guide

in rats: It was investigated the effect of ST1936 (5-10-20 mg/kg/ip) on dialysate DA, NA and 5-HT in the medial prefrontal cortex (PFCX) and in the shell and core of the nucleus accumbens (NAc). Systemic administration of ST1936 dose-dependently increased dialysate DA and NA in the NAc shell and PFCX and to a lesser extent in the NAc core.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:00:38 GMT 2023` Edited by `admin` on `Sat Dec 16 18:00:38 GMT 2023`
Record UNII	4R5ZNV2CHC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ST-1936

Code

English

5-CHLORO-N,N,2-TRIMETHYL-1H-INDOLE-3-ETHANAMINE

Systematic Name

English

1H-INDOLE-3-ETHANAMINE, 5-CHLORO-N,N,2-TRIMETHYL-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID001045649