Luvomeran

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 14:30:02 GMT 2025` Edited by `admin` on `Wed Apr 02 14:30:02 GMT 2025`
Nucleic Acid Type	mRNA VACCINE
Sequence Type	COMPLETE
Record UNII	4HS3TYX8MY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CX-025984

Preferred Name

English

Luvomeran

Official Name

English

luvomeran [INN]

Common Name

English

messenger RNA (mRNA), 5' capped, encoding codonoptimised human cystic fibrosis transmembrane conductance regulator (hCFTR; channel conductancecontrolling ATPase, cAMP-dependent chloride channel, ATP-binding cassette sub-family C member 7), flanked by 5'

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted human cystic fibrosis transmembrane conductance regulator protein plus 5?-and 3?-untranslated flanking region-containing poly(A)-tailed messenger CX-025984), i

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C206938

Created by admin on Wed Apr 02 14:30:02 GMT 2025 , Edited by admin on Wed Apr 02 14:30:02 GMT 2025

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INN

12953

Created by admin on Wed Apr 02 14:30:02 GMT 2025 , Edited by admin on Wed Apr 02 14:30:02 GMT 2025

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CAS

2845125-98-4

Created by admin on Wed Apr 02 14:30:02 GMT 2025 , Edited by admin on Wed Apr 02 14:30:02 GMT 2025

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SMS_ID

300000046918

Created by admin on Wed Apr 02 14:30:02 GMT 2025 , Edited by admin on Wed Apr 02 14:30:02 GMT 2025

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FDA UNII

4HS3TYX8MY

Created by admin on Wed Apr 02 14:30:02 GMT 2025 , Edited by admin on Wed Apr 02 14:30:02 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_4761	4761 / 4762
	1_4762	1 / 4762

Linkage	Site Range	Site Count
Phosphate	1_2-1_4762	4761 / 4761

Related Record Type Details


					4HS3TYX8MY

Luvomeran

ACTIVE MOIETY

Comments:

messenger RNA encoding cystic fibrosis transmembrane regulator (CFTR)

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
5? UTR	NUCLEIC ACID FEATURE
3? UTR	NUCLEIC ACID FEATURE
PolyA tail	NUCLEIC ACID FEATURE
ORF	NUCLEIC ACID FEATURE