Firicabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 20:00:24 GMT 2023` Edited by `admin` on `Sat Dec 16 20:00:24 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	T cells enriched for CD4/CD8
Record UNII	4BEJ6K4DQ9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Firicabtagene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human CD22. The expressed transgene comprises the granul

Common Name

English

firicabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

4BEJ6K4DQ9

Created by admin on Sat Dec 16 20:00:24 GMT 2023 , Edited by admin on Sat Dec 16 20:00:24 GMT 2023

PRIMARY

INN

12829

Created by admin on Sat Dec 16 20:00:24 GMT 2023 , Edited by admin on Sat Dec 16 20:00:24 GMT 2023

PRIMARY

Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT MAY BE PRESENT -> PARENT

Comments:

secrete interferon gamma in esponse to CD22 expressing tumour cell lines

Amount:


					RCH7C9TW12

B-CELL RECEPTOR CD22

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					4BEJ6K4DQ9

Firicabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CULTURE	EXPANSION	BIOLOGICAL	HUMAN AB SERUM	S6RLS52G3S
CULTURE	EXPANSION	BIOLOGICAL	HUMAN IL-15	HRJ300HC9W
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION	Firicabtagene autoleucel lentiviral vector	QDR2XGC8SL

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Firicabtagene autoleucel transgene insert	A65Z4B94MY
VECTOR EXPRESSED PROTEIN					Firicabtagene autoleucel expressed chimeric antigen receptor (CAR) targeting human CD22	XTR2W4N9GV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`ZLW14X2D30` CD3