Firicabtagene Autoleucel

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:59:58 GMT 2025` Edited by `admin` on `Wed Apr 02 17:59:58 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	t cells enriched for cd4/cd8
Record UNII	4BEJ6K4DQ9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Autologous T lymphocytes obtained from peripheral blood by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human CD22. The expressed transgene comprises the granul

Preferred Name

English

Firicabtagene Autoleucel

Official Name

English

firicabtagene autoleucel [INN]

Common Name

English

FIRICABTAGENE AUTOLEUCEL [USAN]

Common Name

English

Code System Code Type Description

SMS_ID

300000054849

Created by admin on Wed Apr 02 17:59:58 GMT 2025 , Edited by admin on Wed Apr 02 17:59:58 GMT 2025

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NCI_THESAURUS

C203126

Created by admin on Wed Apr 02 17:59:58 GMT 2025 , Edited by admin on Wed Apr 02 17:59:58 GMT 2025

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USAN

MN-211

Created by admin on Wed Apr 02 17:59:58 GMT 2025 , Edited by admin on Wed Apr 02 17:59:58 GMT 2025

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FDA UNII

4BEJ6K4DQ9

Created by admin on Wed Apr 02 17:59:58 GMT 2025 , Edited by admin on Wed Apr 02 17:59:58 GMT 2025

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INN

12829

Created by admin on Wed Apr 02 17:59:58 GMT 2025 , Edited by admin on Wed Apr 02 17:59:58 GMT 2025

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Related Record Type Details


					P050J5FWC5

INTERFERON GAMMA

CONSTITUENT MAY BE PRESENT -> PARENT

Comments:

secrete interferon gamma in esponse to CD22 expressing tumour cell lines

Amount:


					RCH7C9TW12

B-CELL RECEPTOR CD22

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					4BEJ6K4DQ9

Firicabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL		INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CULTURE	EXPANSION	BIOLOGICAL		HUMAN AB SERUM	S6RLS52G3S
CULTURE	EXPANSION	BIOLOGICAL		HUMAN IL-15	HRJ300HC9W
CULTURE	ACTIVATOR	BIOLOGICAL		ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION		Firicabtagene autoleucel lentiviral vector	QDR2XGC8SL

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Firicabtagene autoleucel transgene insert	A65Z4B94MY
VECTOR EXPRESSED PROTEIN					Firicabtagene autoleucel expressed chimeric antigen receptor (CAR) targeting human CD22	XTR2W4N9GV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`ZLW14X2D30` CD3