FUTIBATINIB

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H22N6O3
Molecular Weight	418.4485
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CCN(C1)C(=O)C=C)N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C24

InChI

InChIKey=KEIPNCCJPRMIAX-HNNXBMFYSA-N

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H22N6O3
Molecular Weight	418.4485
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Potency
Fibroblast growth factor receptor 1 45 Target ID: CHEMBL3650 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30600916	Inhibitor 8297	3.9 nM [IC50]
Fibroblast growth factor receptor 2 25 Target ID: CHEMBL4142 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30600916	Inhibitor 8297	1.3 nM [IC50]
Fibroblast growth factor receptor 3 32 Target ID: CHEMBL2742 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30600916	Inhibitor 8297	1.6 nM [IC50]
Fibroblast growth factor receptor 4 16 Target ID: CHEMBL3973 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30600916	Inhibitor 8297	8.3 nM [IC50]

PubMed

Title	Date	PubMed
TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.	2019 Aug	31109923
Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.	2019 Dec	31043681
TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure.	2019 Feb 19	30600916

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:08:45 UTC 2023` Edited by `admin` on `Sat Dec 16 09:08:45 UTC 2023`
Record UNII	4B93MGE4AL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FUTIBATINIB

Official Name

English

LYTGOBI

Brand Name

English

Futibatinib [WHO-DD]

Common Name

English

FUTIBATINIB [USAN]

Common Name

English

futibatinib [INN]

Common Name

English

FGFR-IN-1

Common Name

English

TAS-120

Code

English

FUTIBATINIB [JAN]

Common Name

English

2-PROPEN-1-ONE, 1-((3S)-3-(4-AMINO-3-(2-(3,5-DIMETHOXYPHENYL)ETHYNYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-1-YL)-1-PYRROLIDINYL)-

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/19/2146