Peluntamig

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:18:43 GMT 2025` Edited by `admin` on `Wed Apr 02 14:18:43 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	4A6ZWS8R8E
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PT-217

Preferred Name

English

Peluntamig

Official Name

English

immunoglobulin H-gamma1_L-kappa, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3) and anti-[Homo sapiens DLL3 (delta-like ligand 3, delta like canonical Notch ligand 3)], bispecific;

Common Name

English

Immunoglobulin G1 [350-cysteine,367-serine,369-alanine,408-valine], anti-(human notch ligand DLL3) (human-Mus musculus monoclonal PT217 ?1-chain), disulfide with human-Mus musculus monoclonal PT217 ?-chain, (227?223?),(230?226?),(350?351?)-tris(disulfide

Common Name

English

peluntamig [INN]

Common Name

English

H-gamma1 heavy chain anti-CD47 (1-444) [VH (Homo sapiens IGHV1-46*01 (88.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114) -Homo sapiens IGHG1*01 G1m17,1 CH1 K120, CH3 D12, L14, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 K120 (21

Common Name

English

Bispecific Antibody against DLL3 and CD47

Common Name

English

PT217

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

880922

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

Code System Code Type Description

INN

13261

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

PRIMARY

CAS

2928515-21-1

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

PRIMARY

NCI_THESAURUS

C199289

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

PRIMARY

FDA UNII

4A6ZWS8R8E

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

PRIMARY

SMS_ID

300000056811

Created by admin on Wed Apr 02 14:18:43 GMT 2025 , Edited by admin on Wed Apr 02 14:18:43 GMT 2025

PRIMARY

From	To
2_364	2_422
1_350	2_351
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_258	2_318
2_217	4_214
2_141	2_197
2_22	2_96
1_368	1_426
1_262	1_322
1_230	2_226
1_227	2_223
1_221	3_214
1_145	1_201
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_294

Related Record Type Details


					90DHW5TM9S

LEUKOCYTE SURFACE ANTIGEN CD47

TARGET -> INHIBITOR

Amount:


					Y776670LBR

.DELTA.-LIKE PROTEIN 3

TARGET->LIGAND

Amount:

Related Record Type Details


					4A6ZWS8R8E

ACTIVE MOIETY

Comments:

A bispecific antibody with dual functions of targeting DLL3-expressing cancer cells and blocking the CD47 “don’t eat me” signal on the same cancer cells is expected to activate the macrophages of innate immunity to specifically kill cancer cells that express both DLL3 and CD47

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL

MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL