LEUKOCYTE SURFACE ANTIGEN CD47

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	90DHW5TM9S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANTIGENIC SURFACE DETERMINANT PROTEIN OA3

Preferred Name

English

LEUKOCYTE SURFACE ANTIGEN CD47

Common Name

English

PROTEIN MER6

Common Name

English

INTEGRIN-ASSOCIATED PROTEIN

Common Name

English

MER6

Common Name

English

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Code System

Code

Type

Description

UNIPROT

Q08722

PRIMARY

FDA UNII

90DHW5TM9S

PRIMARY

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Subunit 0

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From	To
1_15	1_245
1_23	1_96

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_5
N	1_16
N	1_32
N	1_55
N	1_93

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Related Record

Type

Details


					W6284A5K8N

URABRELIMAB

INHIBITOR -> TARGET


					BDN84I1TFE

LETAPLIMAB

INHIBITOR -> TARGET

Amount:


					Q8A4U1Z9N2

ONTORPACEPT

INHIBITOR -> TARGET


					44D51T6SZH

Maplirpacept

INHIBITOR -> TARGET

Amount:


					65RC2F9XAB

CPO-107

LIGAND->TARGET

Comments:

CPO107 binds to CD47 on the target cell surface blocking the CD47/SIRP? interaction between the target cell and macrophage, thus, promotes the antibody-dependent cellular phagocytosis (ADCP).

Interaction Type:

IN-VIVO

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_71]				DEXFOSFOSERINE	VI4F0K069V

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 33500 Da (average)

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