Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 13:26:31 UTC 2023
by
admin
on
Sat Dec 16 13:26:31 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
90DHW5TM9S
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
Q08722
Created by
admin on Sat Dec 16 13:26:31 UTC 2023 , Edited by admin on Sat Dec 16 13:26:31 UTC 2023
|
PRIMARY | |||
|
90DHW5TM9S
Created by
admin on Sat Dec 16 13:26:31 UTC 2023 , Edited by admin on Sat Dec 16 13:26:31 UTC 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_15 | 1_245 |
| 1_23 | 1_96 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_5 |
| N | 1_16 |
| N | 1_32 |
| N | 1_55 |
| N | 1_93 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
|
||
|
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
|
||
|
|
LIGAND->TARGET |
CPO107 binds to CD47 on the target
cell surface blocking the CD47/SIRPα interaction between the target cell and macrophage, thus, promotes the antibody-dependent cellular phagocytosis (ADCP).
IN-VIVO
|
||
|
INHIBITOR -> TARGET |
|
||
|
|
INHIBITOR -> TARGET |
prevents CD47/SIRPa-mediated signaling, allows the activation of macrophages, through the induction of pro-phagocytic signaling mediated by calreticulin, which is specifically expressed on the surface of tumor cells, and results in specific tumor cell phagocytosis. In addition, blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response and T-mediated cell killing. CD47, a tumor associated antigen expressed on normal, healthy hematopoietic stem cells (HSC), is overexpressed on the surface of a variety of cancer cells. Expression of CD47, and interaction with SIRP-alpha, leads to inhibition of macrophages and protects cancer cells from phagocytosis thereby allowing cancer cells to proliferate.
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
|
INHIBITOR -> TARGET |
IN-VITRO, IN-VIVO
|
||
|
INHIBITOR -> TARGET |
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|