Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.3062 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C2CCCC2=C1O[C@H]3CCNC3
InChI
InChIKey=QDJAYXYEXHVXJV-NSHDSACASA-N
InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.3062 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
ORG 37684 is a selective full agonist of 5-hydroxytryptamine receptor 5-HT2 family with a high selectivity for 5-HT2C in comparison with 5-HT2B and 5-HT2A receptors. It was studied for treatment of depression, but that investigations were discontinued. On animal studies ORG 37684 possessed hypophagic effect, which was exclusively mediated by activation of 5-HT2C receptors. Thus, this compound can be further investigated in using for weight loss.
Originator
Approval Year
Sample Use Guides
To examine the effect of receptor density on agonist efficacy, three agonists of differential efficacies were examined for GTPγ35S binding; a full agonist, Org37684, a partial agonist, quipazine, and a weak partial agonist LSD. Enhancement of GTPγ35S binding by Org37684 (10 μM) ranged from 93 to 101% as normalized to that of 5-HT (10 μM), quipazine from 52 to 67%, and LSD from 23 to 29% in these cell lines, with no appreciable dependence on receptor density.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:09:01 GMT 2023
by
admin
on
Sat Dec 16 19:09:01 GMT 2023
|
| Record UNII |
48QQ8ZTE6C
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
48QQ8ZTE6C
Created by
admin on Sat Dec 16 19:09:01 GMT 2023 , Edited by admin on Sat Dec 16 19:09:01 GMT 2023
|
PRIMARY | |||
|
9794656
Created by
admin on Sat Dec 16 19:09:01 GMT 2023 , Edited by admin on Sat Dec 16 19:09:01 GMT 2023
|
PRIMARY | |||
|
ORG-37684
Created by
admin on Sat Dec 16 19:09:01 GMT 2023 , Edited by admin on Sat Dec 16 19:09:01 GMT 2023
|
PRIMARY | |||
|
436083-07-7
Created by
admin on Sat Dec 16 19:09:01 GMT 2023 , Edited by admin on Sat Dec 16 19:09:01 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> AGONIST |
|
||
|
TARGET -> AGONIST |
|
