Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H20N4O |
| Molecular Weight | 320.3883 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CC1=CC=C(C=C1)C2=NC3=C4N2CCNC(=O)C4=CC=C3
InChI
InChIKey=SEKJSSBJKFLZIT-UHFFFAOYSA-N
InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
| Molecular Formula | C19H20N4O |
| Molecular Weight | 320.3883 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14522929 | https://www.ncbi.nlm.nih.gov/pubmed/14709739Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16322308
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14522929 | https://www.ncbi.nlm.nih.gov/pubmed/14709739
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16322308
AG-14361 binds to the catalytic domain of PARP-1 and is a potent, selective inhibitor. AG-14361 is a selective inhibitor of PARP-1 with Ki50 value <5 nM. AG-14361 is the first high-potency PARP-1 inhibitor with the specificity and in vivo activity to enhance chemotherapy and radiation therapy of human cancer.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. | 2003 Jan 16 |
|
| Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. | 2003 Sep 15 |
|
| Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. | 2004 Feb 1 |
|
| Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. | 2004 Jan 7 |
|
| The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. | 2005 Dec 1 |
|
| Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. | 2010 Oct |
|
| Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. | 2012 Nov 1 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:00:07 GMT 2023
by
admin
on
Sat Dec 16 09:00:07 GMT 2023
|
| Record UNII |
48N0U0K50I
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
328543-09-5
Created by
admin on Sat Dec 16 09:00:07 GMT 2023 , Edited by admin on Sat Dec 16 09:00:07 GMT 2023
|
PRIMARY | |||
|
9840076
Created by
admin on Sat Dec 16 09:00:07 GMT 2023 , Edited by admin on Sat Dec 16 09:00:07 GMT 2023
|
PRIMARY | |||
|
48N0U0K50I
Created by
admin on Sat Dec 16 09:00:07 GMT 2023 , Edited by admin on Sat Dec 16 09:00:07 GMT 2023
|
PRIMARY | |||
|
DTXSID80186513
Created by
admin on Sat Dec 16 09:00:07 GMT 2023 , Edited by admin on Sat Dec 16 09:00:07 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
