ROBENIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13Cl2N5
Molecular Weight	334.203
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)\C=N\NC(=N)N\N=C\C2=CC=C(Cl)C=C2

InChI

InChIKey=MOOFYEJFXBSZGE-LQGKIZFRSA-N

InChI=1S/C15H13Cl2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)/b19-9+,20-10+

HIDE SMILES / InChI

Molecular Formula	C15H13Cl2N5
Molecular Weight	334.203
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://www.zoetisus.com/_locale-assets/mcm-portal-assets/msds_pi/pi/robenz.pdf | https://www.ncbi.nlm.nih.gov/pubmed/1118187

Robenidine (l,3-6ts (p-chlorobenzylidenamino) guanidine hydrochloride) is an effective anticoccidial, first introduced by Kantor, Kennett, Waletzky & Tomcufcik (1970). It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Eimeria tenella 10 Target ID: CHEMBL612854 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1792230	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f86501dd-61c8-451b-ad5e-562e349fbd37&type=display https://www.zoetisus.com/_locale-assets/mcm-portal-assets/msds_pi/pi/robenz.pdf https://www.ncbi.nlm.nih.gov/pubmed/1792230	Curative		Approved 8429	Robenz Approved Use For the prevention of coccidiosis in broiler chickens caused by and Eimeria acervulina, E. mivati, E. maxima, E. brunetti, E. tenella, E. necatrix Launch Date 2009

PubMed

Title	Date	PubMed
In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.	1990 Aug	2221857

Patents

Sample Use Guides

In Vivo Use Guide

Chickens: Mix 1 pound of Robenz® (Robenidine Hydrochloride) Type A Medicated Article in one ton of feed to provide 30 grams per ton (0.0033%) robenidine hydrochloride concentration in feed. Feed continuously as the sole ration.

Route of Administration: Oral

In Vitro Use Guide

Robenidine was active against MRSA and VRE with MIC's of 8.1 and 4.7 uM, respectively.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:34 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:34 GMT 2023`
Record UNII	4888ME6C4E
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ROBENIDINE

Official Name

English

robenidine [INN]

Common Name

English

ROBENIDINE [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 558.515