ROBENIDINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13Cl2N5
Molecular Weight	334.203
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)\C=N\NC(=N)N\N=C\C2=CC=C(Cl)C=C2

InChI

InChIKey=MOOFYEJFXBSZGE-LQGKIZFRSA-N

InChI=1S/C15H13Cl2N5/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12/h1-10H,(H3,18,21,22)/b19-9+,20-10+

HIDE SMILES / InChI

Molecular Formula	C15H13Cl2N5
Molecular Weight	334.203
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://www.zoetisus.com/_locale-assets/mcm-portal-assets/msds_pi/pi/robenz.pdf | https://www.ncbi.nlm.nih.gov/pubmed/1118187

Robenidine (l,3-6ts (p-chlorobenzylidenamino) guanidine hydrochloride) is an effective anticoccidial, first introduced by Kantor, Kennett, Waletzky & Tomcufcik (1970). It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Eimeria tenella 10 Target ID: CHEMBL612854 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1792230	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f86501dd-61c8-451b-ad5e-562e349fbd37&type=display https://www.zoetisus.com/_locale-assets/mcm-portal-assets/msds_pi/pi/robenz.pdf https://www.ncbi.nlm.nih.gov/pubmed/1792230	Curative		Approved 8583	Robenz Approved Use For the prevention of coccidiosis in broiler chickens caused by and Eimeria acervulina, E. mivati, E. maxima, E. brunetti, E. tenella, E. necatrix Launch Date 2009

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153 CYP2C19 2057 CYP19A1 429

Drug as perpetrator

Target	Modality	Activity
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 4.0	inconclusive [IC50 3.4671 uM]
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 79.0	no
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 13.0	yes [IC50 13.8029 uM]
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 79.0	yes [IC50 15.4871 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 3.0	yes [IC50 2.1876 uM]
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/9570438#section=BioAssay-Results Page: 4.0	yes [IC50 3.6258 uM]

PubMed

Title	Date	PubMed
In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.	1990-08	2221857

Patents

Sample Use Guides

In Vivo Use Guide

Chickens: Mix 1 pound of Robenz® (Robenidine Hydrochloride) Type A Medicated Article in one ton of feed to provide 30 grams per ton (0.0033%) robenidine hydrochloride concentration in feed. Feed continuously as the sole ration.

Route of Administration: Oral

In Vitro Use Guide

Robenidine was active against MRSA and VRE with MIC's of 8.1 and 4.7 uM, respectively.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:05 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:05 GMT 2025`
Record UNII	4888ME6C4E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ROBENIDINE

Official Name

English

ROBENIDINE [MI]

Preferred Name

English

robenidine [INN]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 558.515