Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H13Cl2N5.ClH |
Molecular Weight | 370.664 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.ClC1=CC=C(C=C1)\C=N\NC(=N)N\N=C\C2=CC=C(Cl)C=C2
InChI
InChIKey=LTWIBTYLSRDGHP-HCURTGQUSA-N
InChI=1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C15H13Cl2N5 |
Molecular Weight | 334.203 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Optical Activity | NONE |
Robenidine (l,3-6ts (p-chlorobenzylidenamino) guanidine hydrochloride) is
an effective anticoccidial, first introduced by Kantor, Kennett, Waletzky &
Tomcufcik (1970). It does not affect the earliest stages in the coccidial life-cycle and
its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1118187
Curator's Comment: Robenidine was first introduced by Kantor, Kennett, Waletzky & Tomcufcik in 1970.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL612854 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1792230 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Robenz Approved UseFor the prevention of coccidiosis in broiler
chickens caused by and Eimeria acervulina,
E. mivati, E. maxima, E. brunetti, E. tenella, E. necatrix Launch Date2009 |
Sample Use Guides
Chickens: Mix 1 pound of Robenz® (Robenidine Hydrochloride) Type A Medicated Article in one ton of feed to provide 30 grams per ton (0.0033%) robenidine hydrochloride concentration in feed. Feed continuously as the sole ration.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26765953
Robenidine was active against MRSA and VRE with MIC's of 8.1 and 4.7 uM, respectively.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:04:47 GMT 2023
by
admin
on
Fri Dec 15 16:04:47 GMT 2023
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Record UNII |
8STT15Y392
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Record Status |
Validated (UNII)
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Record Version |
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CFR |
21 CFR 556.580
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NCI_THESAURUS |
C277
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m9641
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247-307-8
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8STT15Y392
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DTXSID101017219
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25875-50-7
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ACTIVE MOIETY |