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Details

Stereochemistry ACHIRAL
Molecular Formula C15H13Cl2N5.ClH
Molecular Weight 370.664
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of ROBENIDINE HYDROCHLORIDE

SMILES

Cl.ClC1=CC=C(C=C1)\C=N\NC(=N)N\N=C\C2=CC=C(Cl)C=C2

InChI

InChIKey=LTWIBTYLSRDGHP-HCURTGQUSA-N
InChI=1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C15H13Cl2N5
Molecular Weight 334.203
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE

Robenidine (l,3-6ts (p-chlorobenzylidenamino) guanidine hydrochloride) is an effective anticoccidial, first introduced by Kantor, Kennett, Waletzky & Tomcufcik (1970). It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Originator

Curator's Comment: Robenidine was first introduced by Kantor, Kennett, Waletzky & Tomcufcik in 1970.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Robenz

Approved Use

For the prevention of coccidiosis in broiler chickens caused by and Eimeria acervulina, E. mivati, E. maxima, E. brunetti, E. tenella, E. necatrix

Launch Date

2009
PubMed

PubMed

TitleDatePubMed
In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.
1990 Aug
Patents

Sample Use Guides

Chickens: Mix 1 pound of Robenz® (Robenidine Hydrochloride) Type A Medicated Article in one ton of feed to provide 30 grams per ton (0.0033%) robenidine hydrochloride concentration in feed. Feed continuously as the sole ration.
Route of Administration: Oral
Robenidine was active against MRSA and VRE with MIC's of 8.1 and 4.7 uM, respectively.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:04:47 GMT 2023
Edited
by admin
on Fri Dec 15 16:04:47 GMT 2023
Record UNII
8STT15Y392
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ROBENIDINE HYDROCHLORIDE
GREEN BOOK   MART.   MI   USAN  
USAN  
Official Name English
ROBENIDINE HYDROCHLORIDE [USAN]
Common Name English
1,3-BIS((P-CHLOROBENZYLIDENE)AMINO)GUANIDINE MONOHYDROCHLORIDE
Common Name English
CARBONIMIDIC DIHYDRAZIDE, BIS((4-CHLOROPHENYL)METHYLENE)-, MONOHYDROCHLORIDE
Common Name English
ROBENZIDINE
Common Name English
ROBENIDINE HCL
Common Name English
ROBENIDINE HYDROCHLORIDE [MI]
Common Name English
ROBENIDINE HYDROCHLORIDE [MART.]
Common Name English
ROBENIDINE HYDROCHLORIDE [GREEN BOOK]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 556.580
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
NCI_THESAURUS C277
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
Code System Code Type Description
MERCK INDEX
m9641
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
247-307-8
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
PUBCHEM
9570437
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
NCI_THESAURUS
C76428
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
DAILYMED
8STT15Y392
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
RXCUI
1311553
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY RxNorm
FDA UNII
8STT15Y392
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID101017219
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
ChEMBL
CHEMBL97137
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
CAS
25875-50-7
Created by admin on Fri Dec 15 16:04:47 GMT 2023 , Edited by admin on Fri Dec 15 16:04:47 GMT 2023
PRIMARY
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