THIAZESIM

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22N2OS
Molecular Weight	326.456
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCN1C2=C(SC(CC1=O)C3=CC=CC=C3)C=CC=C2

InChI

InChIKey=QJJXOEFWXSQISU-UHFFFAOYSA-N

InChI=1S/C19H22N2OS/c1-20(2)12-13-21-16-10-6-7-11-17(16)23-18(14-19(21)22)15-8-4-3-5-9-15/h3-11,18H,12-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H22N2OS
Molecular Weight	326.456
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4867805 | https://www.ncbi.nlm.nih.gov/pubmed/4967224 | https://www.ncbi.nlm.nih.gov/pubmed/400995

Thiazesim (also known as ) is a benzothiazepine derivative patented by Olin Mathieson Chemical Corp. as an oral anti-depressant and tranquilizer useful in the treatment of Parkinsonism. Thiazesim is chemically related to the tranquilizing drugs chlordiazepoxide and diazepam but possesses a unique action on the limbic system, namely a selective depression of the lateral amygdaloid nucleus in experimental animals. Thiazesim shows potent anti-depressant activity in clinical trials.

Originator

Approval Year

PubMed

Title	Date	PubMed
The effects of thiazesim, LSD-25, and bilateral lesions of the amygdalae on the release of a suppressed response.	1966	4971577
The pathology of a cross-over trial: (thiazesim--a new anti-depressant drug).	1968 Feb	4867805

Patents

Sample Use Guides

In Vivo Use Guide

100 mg. t.d.s., and increased after one week if no clinical effects had been noted

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:27:59 GMT 2023` Edited by `admin` on `Fri Dec 15 18:27:59 GMT 2023`
Record UNII	44G76ZB85O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAZESIM

Common Name

English

tiazesim [INN]

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-

Systematic Name

English

THIAZESIM [MI]

Common Name

English

TIAZESIM

Official Name

English

5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-1,5-BENZOTHIAZEPIN-4(5H)-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265