THIAZESIM

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22N2OS
Molecular Weight	326.456
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCN1C2=CC=CC=C2SC(CC1=O)C3=CC=CC=C3

InChI

InChIKey=QJJXOEFWXSQISU-UHFFFAOYSA-N

InChI=1S/C19H22N2OS/c1-20(2)12-13-21-16-10-6-7-11-17(16)23-18(14-19(21)22)15-8-4-3-5-9-15/h3-11,18H,12-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H22N2OS
Molecular Weight	326.456
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4867805 | https://www.ncbi.nlm.nih.gov/pubmed/4967224 | https://www.ncbi.nlm.nih.gov/pubmed/400995

Thiazesim (also known as ) is a benzothiazepine derivative patented by Olin Mathieson Chemical Corp. as an oral anti-depressant and tranquilizer useful in the treatment of Parkinsonism. Thiazesim is chemically related to the tranquilizing drugs chlordiazepoxide and diazepam but possesses a unique action on the limbic system, namely a selective depression of the lateral amygdaloid nucleus in experimental animals. Thiazesim shows potent anti-depressant activity in clinical trials.

Originator

Approval Year

PubMed

Title	Date	PubMed
The pathology of a cross-over trial: (thiazesim--a new anti-depressant drug).	1968-02	4867805
The effects of thiazesim, LSD-25, and bilateral lesions of the amygdalae on the release of a suppressed response.	1966	4971577

Patents

Sample Use Guides

In Vivo Use Guide

100 mg. t.d.s., and increased after one week if no clinical effects had been noted

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:12:49 GMT 2025` Edited by `admin` on `Mon Mar 31 19:12:49 GMT 2025`
Record UNII	44G76ZB85O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAZESIM

Common Name

English

TIAZESIM

Preferred Name

English

tiazesim [INN]

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-

Systematic Name

English

THIAZESIM [MI]

Common Name

English

5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-1,5-BENZOTHIAZEPIN-4(5H)-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265