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Details

Stereochemistry RACEMIC
Molecular Formula C19H22N2OS
Molecular Weight 326.456
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIAZESIM

SMILES

CN(C)CCN1C2=CC=CC=C2SC(CC1=O)C3=CC=CC=C3

InChI

InChIKey=QJJXOEFWXSQISU-UHFFFAOYSA-N
InChI=1S/C19H22N2OS/c1-20(2)12-13-21-16-10-6-7-11-17(16)23-18(14-19(21)22)15-8-4-3-5-9-15/h3-11,18H,12-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C19H22N2OS
Molecular Weight 326.456
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Thiazesim (also known as ) is a benzothiazepine derivative patented by Olin Mathieson Chemical Corp. as an oral anti-depressant and tranquilizer useful in the treatment of Parkinsonism. Thiazesim is chemically related to the tranquilizing drugs chlordiazepoxide and diazepam but possesses a unique action on the limbic system, namely a selective depression of the lateral amygdaloid nucleus in experimental animals. Thiazesim shows potent anti-depressant activity in clinical trials.

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
100 mg. t.d.s., and increased after one week if no clinical effects had been noted
Route of Administration: Oral
Substance Class Chemical
Record UNII
44G76ZB85O
Record Status Validated (UNII)
Record Version