THIAZESIM HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22N2OS.ClH
Molecular Weight	362.917
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN(C)CCN1C2=C(SC(CC1=O)C3=CC=CC=C3)C=CC=C2

InChI

InChIKey=IUZXQGCIJLIGLS-UHFFFAOYSA-N

InChI=1S/C19H22N2OS.ClH/c1-20(2)12-13-21-16-10-6-7-11-17(16)23-18(14-19(21)22)15-8-4-3-5-9-15;/h3-11,18H,12-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	C19H22N2OS
Molecular Weight	326.456
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4867805 | https://www.ncbi.nlm.nih.gov/pubmed/4967224 | https://www.ncbi.nlm.nih.gov/pubmed/400995

Thiazesim (also known as ) is a benzothiazepine derivative patented by Olin Mathieson Chemical Corp. as an oral anti-depressant and tranquilizer useful in the treatment of Parkinsonism. Thiazesim is chemically related to the tranquilizing drugs chlordiazepoxide and diazepam but possesses a unique action on the limbic system, namely a selective depression of the lateral amygdaloid nucleus in experimental animals. Thiazesim shows potent anti-depressant activity in clinical trials.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

100 mg. t.d.s., and increased after one week if no clinical effects had been noted

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:59:10 GMT 2023` Edited by `admin` on `Fri Dec 15 17:59:10 GMT 2023`
Record UNII	4CIH6N1U25
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAZESIM HYDROCHLORIDE

Official Name

English

NSC-169509

Code

English

THIAZESIM HYDROCHLORIDE [MI]

Common Name

English

ALTINIL

Brand Name

English

SQ-10496

Code

English

5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one monohydrochloride

Systematic Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-PHENYL-, MONOHYDROCHLORIDE

Common Name

English

THIAZESIM HYDROCHLORIDE [USAN]

Common Name

English

SQ 10,496

Code

English

TIAZESIM HYDROCHLORIDE

Common Name

English

THIAZESIM HCL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265