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Details

Stereochemistry ACHIRAL
Molecular Formula C27H26F5N7O3
Molecular Weight 591.5325
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACTB-1003

SMILES

COCC1=C(CN2CCOCC2)N3N=CN=C(N)C3=C1C4=CC(F)=C(NC(=O)NC5=C(F)C=CC(=C5)C(F)(F)F)C=C4

InChI

InChIKey=GZPJCJKUZPUFAL-UHFFFAOYSA-N
InChI=1S/C27H26F5N7O3/c1-41-13-17-22(12-38-6-8-42-9-7-38)39-24(25(33)34-14-35-39)23(17)15-2-5-20(19(29)10-15)36-26(40)37-21-11-16(27(30,31)32)3-4-18(21)28/h2-5,10-11,14H,6-9,12-13H2,1H3,(H2,33,34,35)(H2,36,37,40)

HIDE SMILES / InChI

Molecular Formula C27H26F5N7O3
Molecular Weight 591.5325
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

ACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase). The multi-activity of ACTB- 1003 translates to in vivo efficacy with dose-dependent tumor growth inhibition in a variety of histological cancers including lung, breast and colorectal. Eddingpharm acquired worldwide rights to small molecule drug assets including ACTB1003 from ACT Biotech. Eddingpharm plans a phase I trial for Cancer in USA.

Originator

Curator's Comment: # Bayer

Approval Year

Sample Use Guides

In Vitro Use Guide
Curator's Comment: ACTB-1003 is highly active with dose-dependent tumor growth inhibition in cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1. OPM2 cells harbor the FGFR3 t(4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression.
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:51:29 GMT 2023
Edited
by admin
on Sat Dec 16 09:51:29 GMT 2023
Record UNII
44750KD9OE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACTB-1003
Common Name English
UREA, N-(4-(4-AMINO-6-(METHOXYMETHYL)-7-(4-MORPHOLINYLMETHYL)PYRROLO(2,1-F)(1,2,4)TRIAZIN-5-YL)-2-FLUOROPHENYL)-N'-(2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL)-
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C164211
Created by admin on Sat Dec 16 09:51:29 GMT 2023 , Edited by admin on Sat Dec 16 09:51:29 GMT 2023
PRIMARY
CAS
939805-30-8
Created by admin on Sat Dec 16 09:51:29 GMT 2023 , Edited by admin on Sat Dec 16 09:51:29 GMT 2023
PRIMARY
PUBCHEM
23653175
Created by admin on Sat Dec 16 09:51:29 GMT 2023 , Edited by admin on Sat Dec 16 09:51:29 GMT 2023
PRIMARY
FDA UNII
44750KD9OE
Created by admin on Sat Dec 16 09:51:29 GMT 2023 , Edited by admin on Sat Dec 16 09:51:29 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY