Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C6H3Cl3O.C4H10N2 |
| Molecular Weight | 481.028 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CNCCN1.OC2=CC(Cl)=C(Cl)C=C2Cl.OC3=CC(Cl)=C(Cl)C=C3Cl
InChI
InChIKey=BNVFYGMONODIGW-UHFFFAOYSA-N
InChI=1S/2C6H3Cl3O.C4H10N2/c2*7-3-1-5(9)6(10)2-4(3)8;1-2-6-4-3-5-1/h2*1-2,10H;5-6H,1-4H2
| Molecular Formula | C4H10N2 |
| Molecular Weight | 86.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H3Cl3O |
| Molecular Weight | 197.446 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Solid phase extraction of polyhalogenated pollutants from freshwater using chemically modified multi-walled carbon nanotubes and their determination by gas chromatography. | 2009-04 |
|
| Levels of metals and organic substances in workers at a hazardous waste incinerator: a follow-up study. | 2009-03 |
|
| Biological treatment of 2,4,6-trichlorophenol (TCP) containing wastewater in a hybrid bioreactor system with effluent recycle. | 2009-02 |
|
| Evaluation of various tests for the diagnosis of soil contamination by 2,4,5-trichlorophenol (2,4,5-TCP). | 2008-12 |
|
| Dioxins and cardiovascular disease mortality. | 2008-11 |
|
| A margin-of-exposure approach to assessment of noncancer risks of dioxins based on human exposure and response data. | 2008-10 |
|
| Metabolic fate of [14C] chlorophenols in radish (Raphanus sativus), lettuce (Lactuca sativa), and spinach (Spinacia oleracea). | 2008-09-24 |
|
| Intimate coupling of photocatalysis and biodegradation in a photocatalytic circulating-bed biofilm reactor. | 2008-09-01 |
|
| Efficient expression of laccase gene from white-rot fungus Schizophyllum commune in a transgenic tobacco plant. | 2008-09 |
|
| Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum. | 2008-08-15 |
|
| Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. | 2008-08-01 |
|
| Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants. | 2008-08 |
|
| Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures. | 2008-08 |
|
| Novel application of modified multiwalled carbon nanotubes as a solid phase extraction adsorbent for the determination of polyhalogenated organic pollutants in aqueous solution. | 2008-04 |
|
| Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. | 2008-03-05 |
|
| Degradation of 4-fluorophenol by Arthrobacter sp. strain IF1. | 2008-03 |
|
| Acidogenic sequencing batch reactor start-up procedures for induction of 2,4,6-trichlorophenol dechlorination. | 2008-03 |
|
| Factors related to dioxin and furan body levels among Michigan workers. | 2008-02 |
|
| Molecular characterization of brominated persistent pollutants using extended X-ray absorption fine structure (EXAFS) spectroscopy. | 2008-02 |
|
| Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality. | 2008-01 |
|
| Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca(2+). | 2008-01 |
|
| Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 |
|
| Novel surfactant-based adsorbent material for groundwater remediation. | 2007-10-01 |
|
| Concentration of chlorophenols in water to dialkyated catinonic surfactant-silica gel admicelles. | 2007-09-14 |
|
| Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers. | 2007-09 |
|
| Catalytic effect of CuO and other transition metal oxides in formation of dioxins: theoretical investigation of reaction between 2,4,5-trichlorophenol and CuO. | 2007-08-15 |
|
| FaGT2: a multifunctional enzyme from strawberry (Fragaria x ananassa) fruits involved in the metabolism of natural and xenobiotic compounds. | 2007-07 |
|
| Biodegradation of 2,4,5-trichlorophenol by aerobic microbial communities: biorecalcitrance, inhibition, and adaptation. | 2007-06 |
|
| Capillary electrophoresis with in-capillary solid-phase extraction sample cleanup. | 2007-03-15 |
|
| Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides. | 2007-03-14 |
|
| Sequential treatment via Trametes versicolor and UV/TiO2/Ru(x)Se(y) to reduce contaminants in waste water resulting from the bleaching process during paper production. | 2007-03 |
|
| Modified Fenton reaction for trichlorophenol dechlorination by enzymatically generated H2O2 and gluconic acid chelate. | 2007-02 |
|
| Transformation of phenol, catechol, guaiacol and syringol exposed to sodium hypochlorite. | 2007-01 |
|
| Hydrothermal decomposition of pentachlorophenol in subcritical and supercritical water with sodium hydroxide addition. | 2007 |
|
| Determination of endocrine-disrupting compounds in cereals by pressurized liquid extraction and liquid chromatography-mass spectrometry. Study of background contamination. | 2006-12-29 |
|
| Formation of trichlorinated dibenzo-p-dioxins from 2,4-dichlorophenol and 2,4,5-trichlorophenolate: a theoretical study. | 2006-11-13 |
|
| Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population. | 2006-11 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006-11 |
|
| Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. | 2006-10 |
|
| Effects of xenobiotics and steroids on renal and hepatic estrogen metabolism in lake trout. | 2006-09-01 |
|
| Rapid and complete dechlorination of PCP in aqueous solution using Ni-Fe nanoparticles under assistance of ultrasound. | 2006-09 |
|
| In-capillary solid-phase extraction-capillary electrophoresis for the determination of chlorophenols in water. | 2006-08 |
|
| Determination of pentachlorophenol in wastewater irrigated soils and incubated earthworms. | 2006-07-15 |
|
| Dechlorination of chlorophenols by magnesium-silver bimetallic system. | 2006-07-01 |
|
| Using the dual-mode model to describe adsorption of organic pollutants onto an organoclay. | 2006-07-01 |
|
| Role of plant activity and contaminant speciation in aquatic plant assimilation of 2,4,5-trichlorophenol. | 2006-06 |
|
| Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. | 2006-02-02 |
|
| Fenton degradation of organic pollutants in the presence of low-molecular-weight organic acids: cooperative effect of quinone and visible light. | 2006-01-15 |
|
| Narrow-band irradiation of a homologous series of chlorophenols on TiO2: charge-transfer complex formation and reactivity. | 2004-07-06 |
|
| Purification and Properties of Component B of 2,4,5-Trichlorophenoxyacetate Oxygenase from Pseudomonas cepacia AC1100. | 1995-09 |
Sample Use Guides
Triclofenol piperazine was administered as a
salt consisting of 82 per cent 2,4,5-triclofenol
and 18 percent piperazine which was enclosed
in a soft gelatin capsule consisting of a 5 per cent solution of the drug in polyethylene glycol 400. The capsules contained 250 or 100
mg. (base) of the salt. It was administered
with Coca Cola which was followed by hard
candy. Each patient received a single dose of
50 mg./kg. of body weight.
Route of Administration:
Oral
2,4,5-trichlorophenol (2,4,5-TCP) at concentrations from 25-600 ppm increased the size and granularity of the lymphocytes. 2,4,5-TCP induced the strongest and 4,5-DCC induced the weakest changes in these parameters. Moreover, 2,4,5-TCP induced the greatest loss of lymphocyte viability, which was statistically significant at concentrations of 125 and 600 ppm.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:26:11 GMT 2025
by
admin
on
Mon Mar 31 19:26:11 GMT 2025
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| Record UNII |
444YK71BIV
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C250
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