Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C6H3Cl3O.C4H10N2 |
| Molecular Weight | 481.028 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CNCCN1.OC2=C(Cl)C=C(Cl)C(Cl)=C2.OC3=C(Cl)C=C(Cl)C(Cl)=C3
InChI
InChIKey=BNVFYGMONODIGW-UHFFFAOYSA-N
InChI=1S/2C6H3Cl3O.C4H10N2/c2*7-3-1-5(9)6(10)2-4(3)8;1-2-6-4-3-5-1/h2*1-2,10H;5-6H,1-4H2
| Molecular Formula | C6H3Cl3O |
| Molecular Weight | 197.446 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H10N2 |
| Molecular Weight | 86.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purification and Properties of Component B of 2,4,5-Trichlorophenoxyacetate Oxygenase from Pseudomonas cepacia AC1100. | 1995 Sep |
|
| 2,4,5-T and 2,4,5-TCP induce oxidative damage in human erythrocytes: the role of glutathione. | 2004 |
|
| Chlorophenols identification in water using an electronic nose and ANNs (artificial neural networks) classification. | 2004 |
|
| Efficient degradation of toxic organic pollutants with Ni2O3/TiO(2-x)Bx under visible irradiation. | 2004 Apr 21 |
|
| Removal of water pollutants with activated carbons prepared from H3PO4 activation of lignin from kraft black liquors. | 2004 Jul |
|
| Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase. | 2004 Jul |
|
| Evidence for heterodimers of 2,4,5-trichlorophenol on planar lipid layers. A FTIR-ATR investigation. | 2004 Jul 1 |
|
| Determination of weakly acidic endocrine-disrupting compounds by liquid chromatography-mass spectrometry with post-column base addition. | 2004 Nov 12 |
|
| Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine. | 2005 Aug 15 |
|
| Highly efficient NaNO2-catalyzed destruction of trichlorophenol using molecular oxygen. | 2005 Aug 26 |
|
| Ultrasonic dehalogenation and toxicity reduction of trichlorophenol. | 2005 Jan |
|
| Quantification of phenolic metabolites of environmental chemicals in human urine using gas chromatography-tandem mass spectrometry and isotope dilution quantification. | 2005 Jun 25 |
|
| Hydroxyl free radical reactivity toward aqueous chlorinated phenols. | 2005 Mar |
|
| Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana. | 2005 May |
|
| In-capillary solid-phase extraction-capillary electrophoresis for the determination of chlorophenols in water. | 2006 Aug |
|
| Determination of endocrine-disrupting compounds in cereals by pressurized liquid extraction and liquid chromatography-mass spectrometry. Study of background contamination. | 2006 Dec 29 |
|
| Fenton degradation of organic pollutants in the presence of low-molecular-weight organic acids: cooperative effect of quinone and visible light. | 2006 Jan 15 |
|
| Dechlorination of chlorophenols by magnesium-silver bimetallic system. | 2006 Jul 1 |
|
| Using the dual-mode model to describe adsorption of organic pollutants onto an organoclay. | 2006 Jul 1 |
|
| Role of plant activity and contaminant speciation in aquatic plant assimilation of 2,4,5-trichlorophenol. | 2006 Jun |
|
| Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population. | 2006 Nov |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Formation of trichlorinated dibenzo-p-dioxins from 2,4-dichlorophenol and 2,4,5-trichlorophenolate: a theoretical study. | 2006 Nov 13 |
|
| Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. | 2006 Oct |
|
| Rapid and complete dechlorination of PCP in aqueous solution using Ni-Fe nanoparticles under assistance of ultrasound. | 2006 Sep |
|
| Effects of xenobiotics and steroids on renal and hepatic estrogen metabolism in lake trout. | 2006 Sep 1 |
|
| Catalytic effect of CuO and other transition metal oxides in formation of dioxins: theoretical investigation of reaction between 2,4,5-trichlorophenol and CuO. | 2007 Aug 15 |
|
| Modified Fenton reaction for trichlorophenol dechlorination by enzymatically generated H2O2 and gluconic acid chelate. | 2007 Feb |
|
| Transformation of phenol, catechol, guaiacol and syringol exposed to sodium hypochlorite. | 2007 Jan |
|
| FaGT2: a multifunctional enzyme from strawberry (Fragaria x ananassa) fruits involved in the metabolism of natural and xenobiotic compounds. | 2007 Jul |
|
| Biodegradation of 2,4,5-trichlorophenol by aerobic microbial communities: biorecalcitrance, inhibition, and adaptation. | 2007 Jun |
|
| Sequential treatment via Trametes versicolor and UV/TiO2/Ru(x)Se(y) to reduce contaminants in waste water resulting from the bleaching process during paper production. | 2007 Mar |
|
| Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides. | 2007 Mar 14 |
|
| Capillary electrophoresis with in-capillary solid-phase extraction sample cleanup. | 2007 Mar 15 |
|
| Novel surfactant-based adsorbent material for groundwater remediation. | 2007 Oct 1 |
|
| Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers. | 2007 Sep |
|
| Concentration of chlorophenols in water to dialkyated catinonic surfactant-silica gel admicelles. | 2007 Sep 14 |
|
| Novel application of modified multiwalled carbon nanotubes as a solid phase extraction adsorbent for the determination of polyhalogenated organic pollutants in aqueous solution. | 2008 Apr |
|
| Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants. | 2008 Aug |
|
| Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. | 2008 Aug 1 |
|
| Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum. | 2008 Aug 15 |
|
| Evaluation of various tests for the diagnosis of soil contamination by 2,4,5-trichlorophenol (2,4,5-TCP). | 2008 Dec |
|
| Factors related to dioxin and furan body levels among Michigan workers. | 2008 Feb |
|
| Molecular characterization of brominated persistent pollutants using extended X-ray absorption fine structure (EXAFS) spectroscopy. | 2008 Feb |
|
| Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca(2+). | 2008 Jan |
|
| Acidogenic sequencing batch reactor start-up procedures for induction of 2,4,6-trichlorophenol dechlorination. | 2008 Mar |
|
| Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. | 2008 Mar 5 |
|
| Efficient expression of laccase gene from white-rot fungus Schizophyllum commune in a transgenic tobacco plant. | 2008 Sep |
|
| Solid phase extraction of polyhalogenated pollutants from freshwater using chemically modified multi-walled carbon nanotubes and their determination by gas chromatography. | 2009 Apr |
|
| Biological treatment of 2,4,6-trichlorophenol (TCP) containing wastewater in a hybrid bioreactor system with effluent recycle. | 2009 Feb |
Sample Use Guides
Triclofenol piperazine was administered as a
salt consisting of 82 per cent 2,4,5-triclofenol
and 18 percent piperazine which was enclosed
in a soft gelatin capsule consisting of a 5 per cent solution of the drug in polyethylene glycol 400. The capsules contained 250 or 100
mg. (base) of the salt. It was administered
with Coca Cola which was followed by hard
candy. Each patient received a single dose of
50 mg./kg. of body weight.
Route of Administration:
Oral
2,4,5-trichlorophenol (2,4,5-TCP) at concentrations from 25-600 ppm increased the size and granularity of the lymphocytes. 2,4,5-TCP induced the strongest and 4,5-DCC induced the weakest changes in these parameters. Moreover, 2,4,5-TCP induced the greatest loss of lymphocyte viability, which was statistically significant at concentrations of 125 and 600 ppm.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:55:10 GMT 2023
by
admin
on
Fri Dec 15 18:55:10 GMT 2023
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| Record UNII |
444YK71BIV
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C250
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