Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C6H3Cl3O.C4H10N2 |
| Molecular Weight | 481.028 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CNCCN1.OC2=C(Cl)C=C(Cl)C(Cl)=C2.OC3=C(Cl)C=C(Cl)C(Cl)=C3
InChI
InChIKey=BNVFYGMONODIGW-UHFFFAOYSA-N
InChI=1S/2C6H3Cl3O.C4H10N2/c2*7-3-1-5(9)6(10)2-4(3)8;1-2-6-4-3-5-1/h2*1-2,10H;5-6H,1-4H2
| Molecular Formula | C4H10N2 |
| Molecular Weight | 86.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H3Cl3O |
| Molecular Weight | 197.446 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purification and Properties of Component B of 2,4,5-Trichlorophenoxyacetate Oxygenase from Pseudomonas cepacia AC1100. | 1995 Sep |
|
| Reactions of 2,4,6-trichlorophenol on model fly ash: oxidation to CO and CO2, condensation to PCDD/F and conversion into related compounds. | 2001 Feb-Mar |
|
| Fate of the herbicides 2,4,5-T, atrazine, and DNOC in a shallow, anaerobic aquifer investigated by in situ passive diffusive emitters and laboratory batch experiments. | 2001 Nov-Dec |
|
| Evidence of differences in the biotransformation of organic contaminants in three species of freshwater invertebrates. | 2002 |
|
| Electrochemical removal of p-nonylphenol from dilute solutions using a carbon fiber anode. | 2002 Jul |
|
| Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. | 2002 Jun 14 |
|
| Biological monitoring of 2,4,5-trichlorophenol (II): evaluation of an enzyme-linked immunosorbent assay for the analysis of water, urine, and serum samples. | 2002 Nov |
|
| Products of aqueous chlorination of 4-nonylphenol and their estrogenic activity. | 2002 Oct |
|
| A disappearance model for the prediction of trichlorophenol ozonation. | 2003 Apr |
|
| Polychlorinated dibenzo-p-dioxins and dibenzofurans in the air of Seveso, Italy, 26 years after the explosion. | 2003 Apr 15 |
|
| Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy. | 2003 Jun |
|
| Isolation of a glucosyltransferase from Arabidopsis thaliana active in the metabolism of the persistent pollutant 3,4-dichloroaniline. | 2003 May |
|
| Treatment of trichlorophenol by catalytic oxidation process. | 2003 May |
|
| Narrow-band irradiation of a homologous series of chlorophenols on TiO2: charge-transfer complex formation and reactivity. | 2004 Jul 6 |
|
| Hydrophilic and hydrophobic sorption of organic acids by variable charge soils: effect of chemical acidity and acidic functional group. | 2004 Oct 15 |
|
| Ultrasonic dehalogenation and toxicity reduction of trichlorophenol. | 2005 Jan |
|
| Quantification of phenolic metabolites of environmental chemicals in human urine using gas chromatography-tandem mass spectrometry and isotope dilution quantification. | 2005 Jun 25 |
|
| Hydroxyl free radical reactivity toward aqueous chlorinated phenols. | 2005 Mar |
|
| Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana. | 2005 May |
|
| Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. | 2006 Feb 2 |
|
| Fenton degradation of organic pollutants in the presence of low-molecular-weight organic acids: cooperative effect of quinone and visible light. | 2006 Jan 15 |
|
| Using the dual-mode model to describe adsorption of organic pollutants onto an organoclay. | 2006 Jul 1 |
|
| Role of plant activity and contaminant speciation in aquatic plant assimilation of 2,4,5-trichlorophenol. | 2006 Jun |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. | 2006 Oct |
|
| Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers. | 2007 Sep |
|
| Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 |
|
| Novel application of modified multiwalled carbon nanotubes as a solid phase extraction adsorbent for the determination of polyhalogenated organic pollutants in aqueous solution. | 2008 Apr |
|
| Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants. | 2008 Aug |
|
| Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures. | 2008 Aug |
|
| Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum. | 2008 Aug 15 |
|
| Evaluation of various tests for the diagnosis of soil contamination by 2,4,5-trichlorophenol (2,4,5-TCP). | 2008 Dec |
|
| Molecular characterization of brominated persistent pollutants using extended X-ray absorption fine structure (EXAFS) spectroscopy. | 2008 Feb |
|
| Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca(2+). | 2008 Jan |
|
| Acidogenic sequencing batch reactor start-up procedures for induction of 2,4,6-trichlorophenol dechlorination. | 2008 Mar |
|
| Dioxins and cardiovascular disease mortality. | 2008 Nov |
|
| A margin-of-exposure approach to assessment of noncancer risks of dioxins based on human exposure and response data. | 2008 Oct |
|
| Metabolic fate of [14C] chlorophenols in radish (Raphanus sativus), lettuce (Lactuca sativa), and spinach (Spinacia oleracea). | 2008 Sep 24 |
Sample Use Guides
Triclofenol piperazine was administered as a
salt consisting of 82 per cent 2,4,5-triclofenol
and 18 percent piperazine which was enclosed
in a soft gelatin capsule consisting of a 5 per cent solution of the drug in polyethylene glycol 400. The capsules contained 250 or 100
mg. (base) of the salt. It was administered
with Coca Cola which was followed by hard
candy. Each patient received a single dose of
50 mg./kg. of body weight.
Route of Administration:
Oral
2,4,5-trichlorophenol (2,4,5-TCP) at concentrations from 25-600 ppm increased the size and granularity of the lymphocytes. 2,4,5-TCP induced the strongest and 4,5-DCC induced the weakest changes in these parameters. Moreover, 2,4,5-TCP induced the greatest loss of lymphocyte viability, which was statistically significant at concentrations of 125 and 600 ppm.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 01:32:16 UTC 2022
by
admin
on
Sat Dec 17 01:32:16 UTC 2022
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| Record UNII |
444YK71BIV
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C250
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C152737
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5714-82-9
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444YK71BIV
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77747
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M975
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CHEMBL2107709
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DTXSID50972607
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SUB11273MIG
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ACTIVE MOIETY |