DEUDEXTROMETHORPHAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H25NO
Molecular Weight	277.4342
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[2H]C([2H])([2H])OC1=CC=C2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C([2H])([2H])[2H])C2=C1

InChI

InChIKey=MKXZASYAUGDDCJ-QNNIAVNKSA-N

InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1/i1D3,2D3

HIDE SMILES / InChI

Molecular Formula	C18H25NO
Molecular Weight	277.4342
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27232589 | https://www.avanir.com/press/avanir-pharmaceuticals-announces-initiation-phase-iii-trial-avp-786-agitation-patients | https://www.ncbi.nlm.nih.gov/pubmed/28092469 | https://adisinsight.springer.com/drugs/800035704 | https://www.ncbi.nlm.nih.gov/pubmed/30447328

Dextromethorphan D6 is a weak uncompetitive antagonist of the NMDA receptor. Dextromethorphan is also acts at nicotinic receptors, sigma-1 rcptor and serotonin and norepinephrine transporters. The incorporation of deuterium serves to reduce dextromethorphan first-pass liver metabolism. AVP-786 is an oral formulation of a combination of deuterated (d6)-dextromethorphan and an ultra-low dose of quinidine. Avanir Pharmaceuticals launched a phase III development program of AVP-786 for the treatment of agitation in patients with Alzheimer's disease.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:50:00 GMT 2025` Edited by `admin` on `Mon Mar 31 22:50:00 GMT 2025`
Record UNII	427476LZFT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

deudextromethorphan [INN]

Preferred Name

English

DEUDEXTROMETHORPHAN

Official Name

English

DEUDEXTROMETHORPHAN [USAN]

Common Name

English

D6-DM

Common Name

English

(+)-3-D3-METHOXY-17-D3-METHYL-(9.ALPHA.,13.ALPHA.,14.ALPHA.)-MORPHINAN

Common Name

English

MORPHINAN, 3-(METHOXY-D3)-17-(METHYL-D3)-, (9.ALPHA.,13.ALPHA.,14.ALPHA.)-

Systematic Name

English

DEXTROMETHORPHAN D6

Common Name

English

D6-DEXTROMETHORPHAN

Common Name

English

Deudextromethorphan [WHO-DD]

Common Name

English

C10003

Code

English

C-10003

Code

English

CTP-786

Code

English

Code System Code Type Description

RXCUI

2569466