Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H25NO.BrH.H2O |
| Molecular Weight | 376.361 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Br.[H][C@]12CCCC[C@]13CCN([C@H]2CC4=CC=C(OC([2H])([2H])[2H])C=C34)C([2H])([2H])[2H]
InChI
InChIKey=STTADZBLEUMJRG-CDZAPMPLSA-N
InChI=1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1/i1D3,2D3;;
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C18H25NO |
| Molecular Weight | 277.4342 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Dextromethorphan D6 is a weak uncompetitive antagonist of the NMDA receptor. Dextromethorphan is also acts at nicotinic receptors, sigma-1 rcptor and serotonin and norepinephrine transporters. The incorporation of deuterium serves to reduce dextromethorphan first-pass liver metabolism. AVP-786 is an oral formulation of a combination of deuterated (d6)-dextromethorphan and an ultra-low dose of quinidine. Avanir Pharmaceuticals launched a phase III development program of AVP-786 for the treatment of agitation in patients with Alzheimer's disease.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:32:09 GMT 2023
by
admin
on
Sat Dec 16 09:32:09 GMT 2023
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| Record UNII |
W9F1OD5N5J
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| Record Status |
Validated (UNII)
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| Record Version |
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2569465
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C169891
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300000040301
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DE-128
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90479359
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1373497-18-7
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W9F1OD5N5J
Created by
admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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W9F1OD5N5J
Created by
admin on Sat Dec 16 09:32:09 GMT 2023 , Edited by admin on Sat Dec 16 09:32:09 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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ANHYDROUS->SOLVATE | |||
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PARENT -> SALT/SOLVATE |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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