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Details

Stereochemistry RACEMIC
Molecular Formula C34H38N3O7P
Molecular Weight 631.6552
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EFONIDIPINE

SMILES

CC1=C(C(C2=CC=CC(=C2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5

InChI

InChIKey=NSVFSAJIGAJDMR-UHFFFAOYSA-N
InChI=1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45/h5-17,20,31,35H,18-19,21-23H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C34H38N3O7P
Molecular Weight 631.6552
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Efonidipine is a 1,4-dihydropyridine derivative for the treatment of hypertension and angina. Efonidipine exerts its antihypertensive and antianginal effects through blocking L- and T-type calcium channels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
13.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LANDEL

Approved Use

Unknown
Primary
LANDEL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels.
2002 Winter

Sample Use Guides

40 mg once daily for 12 weeks
Route of Administration: Oral
In Vitro Use Guide
Effects of efonidipine on isolated myocardial and aortic preparations was studied. The drug produced concentration-dependent negative chronotropic effects on isolated guinea-pig atrial preparations.The potency was 3.08 x 10(-8)M (EC30).
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:32:43 UTC 2023
Edited
by admin
on Fri Dec 15 16:32:43 UTC 2023
Record UNII
40ZTP2T37Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EFONIDIPINE
INN   MI   WHO-DD  
INN  
Official Name English
Efonidipine [WHO-DD]
Common Name English
efonidipine [INN]
Common Name English
3-PYRIDINECARBOXYLIC ACID, 5-(5,5-DIMETHYL-2-OXIDO-1,3,2-DIOXAPHOSPHORINAN-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-(PHENYL(PHENYLMETHYL)AMINO)ETHYL ESTER
Systematic Name English
EFONIDIPINE [MI]
Common Name English
2-(N-BENZYLANILINO)ETHYL (±)-1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-5-PHOSPHONONICOTINATE, CYCLIC 2,2-DIMETHYLTRIMETHYLENE ESTER
Common Name English
(±)-EFONIDIPINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C333
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID9043988
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
EVMPD
SUB06471MIG
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
MERCK INDEX
m4841
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY Merck Index
CHEBI
135859
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
NCI_THESAURUS
C73026
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
PUBCHEM
119171
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
SMS_ID
100000080517
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
WIKIPEDIA
EFONIDIPINE
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
DRUG BANK
DB09235
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
CAS
111011-63-3
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
FDA UNII
40ZTP2T37Q
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
DRUG CENTRAL
992
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
INN
6852
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
ChEMBL
CHEMBL2074922
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
MESH
C066425
Created by admin on Fri Dec 15 16:32:43 UTC 2023 , Edited by admin on Fri Dec 15 16:32:43 UTC 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY