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Details

Stereochemistry RACEMIC
Molecular Formula C34H38N3O7P.C2H6O.ClH
Molecular Weight 714.185
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EFONIDIPINE HYDROCHLORIDE ETHANOLATE

SMILES

Cl.CCO.CC1=C(C(C2=CC=CC(=C2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5

InChI

InChIKey=IKBJGZQVVVXCEQ-UHFFFAOYSA-N
InChI=1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula C2H6O
Molecular Weight 46.0684
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C34H38N3O7P
Molecular Weight 631.6552
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Efonidipine is a 1,4-dihydropyridine derivative for the treatment of hypertension and angina. Efonidipine exerts its antihypertensive and antianginal effects through blocking L- and T-type calcium channels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
13.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LANDEL

Approved Use

Unknown
Primary
LANDEL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels.
2002 Winter

Sample Use Guides

40 mg once daily for 12 weeks
Route of Administration: Oral
In Vitro Use Guide
Effects of efonidipine on isolated myocardial and aortic preparations was studied. The drug produced concentration-dependent negative chronotropic effects on isolated guinea-pig atrial preparations.The potency was 3.08 x 10(-8)M (EC30).
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:42:23 UTC 2023
Edited
by admin
on Sat Dec 16 05:42:23 UTC 2023
Record UNII
84HJ0Q6TMN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EFONIDIPINE HYDROCHLORIDE ETHANOLATE
JAN   MI  
Common Name English
NZ-105
Code English
EFONIDIPINE HYDROCHLORIDE ETHANOLATE [MI]
Common Name English
(±)-EFONIDIPINE HYDROCHLORIDE ETHANOLATE
Common Name English
LANDEL
Brand Name English
3-PYRIDINECARBOXYLIC ACID, 5-(5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINAN-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-(PHENYL(PHENYLMETHYL)AMINO)ETHYL ESTER, P-OXIDE, MONOHYDROCHLORIDE, COMPD. WITH ETHANOL (1:1)
Common Name English
EFONIDIPINE HYDROCHLORIDE ETHANOLATE [JAN]
Common Name English
Code System Code Type Description
SMS_ID
100000085033
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
EVMPD
SUB21684
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
PUBCHEM
163838
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID5020150
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
CHEBI
135859
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
FDA UNII
84HJ0Q6TMN
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
CAS
111011-76-8
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY
MERCK INDEX
m4841
Created by admin on Sat Dec 16 05:42:23 UTC 2023 , Edited by admin on Sat Dec 16 05:42:23 UTC 2023
PRIMARY Merck Index
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY