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Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H3O2.Co
Molecular Weight 177.0212
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS ACETATE

SMILES

[Co++].CC([O-])=O.CC([O-])=O

InChI

InChIKey=QAHREYKOYSIQPH-UHFFFAOYSA-L
InChI=1S/2C2H4O2.Co/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2

HIDE SMILES / InChI
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C2H3O2
Molecular Weight 59.044
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Acute oral toxicity of inorganic cobalt compounds in rats.
1982 Jun
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990 Dec 1
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines.
2006 Feb
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.
2015 May
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:44 UTC 2023
Edited
by admin
on Fri Dec 15 15:00:44 UTC 2023
Record UNII
3XC4P44U7E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COBALTOUS ACETATE
HSDB   MI  
Common Name English
COBALTOUS ACETATE [MI]
Common Name English
COBALTOUS ACETATE [HSDB]
Common Name English
BIS(ACETATO)COBALT
Common Name English
COBALT(II) ACETATE
Systematic Name English
COBALT ACETATE
WHO-DD  
Systematic Name English
NSC-78410
Code English
COBALT DIACETATE
Systematic Name English
Cobalt acetate [WHO-DD]
Common Name English
ACETIC ACID COBALT(2+) SALT (2:1)
Common Name English
COBALT ACETATE (CO(OAC)2)
Common Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 967
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1045
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 902
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1263
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1147
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Code System Code Type Description
ECHA (EC/EINECS)
200-755-8
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
EPA CompTox
DTXSID6026373
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
CHEBI
85138
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
CAS
71-48-7
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
DAILYMED
3XC4P44U7E
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
EVMPD
SUB13407MIG
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
RXCUI
1369404
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY RxNorm
PUBCHEM
6277
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
MESH
C521309
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
HSDB
997
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
SMS_ID
100000076272
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
WIKIPEDIA
COBALT(II) ACETATE
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
FDA UNII
3XC4P44U7E
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
MERCK INDEX
m3687
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY Merck Index
NSC
78410
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
Related Record Type Details
Structure of COBALTOUS ACETATE TETRAHYDRATE
SOLVATE->ANHYDROUS
Structure of COBALTOUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of COBALTOUS CATION
ACTIVE MOIETY
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